MRI morphologic alterations after liver SBRT

• Verfasst von: Boda-Heggemann, Judit [VerfasserIn]
• Verfasst von: Attenberger, Ulrike [VerfasserIn]
• Verfasst von: Budjan, Johannes [VerfasserIn]
• Verfasst von: Jahnke, Anika [VerfasserIn]
• Verfasst von: Vogel, Lena [VerfasserIn]
• Verfasst von: Simeonova-Chergou, Anna [VerfasserIn]
• Verfasst von: Herskind, Carsten [VerfasserIn]
• Verfasst von: Wenz, Frederik [VerfasserIn]
• Verfasst von: Lohr, Frank [VerfasserIn]
• Titel: MRI morphologic alterations after liver SBRT
• Verf.angabe: Judit Boda-Heggemann, Ulrike Attenberger, Johannes Budjan, Anika Jahnke, Lennart Jahnke, Lena Vogel, Anna O. Simeonova-Chergou, Carsten Herskind, Frederik Wenz, Frank Lohr
• E-Jahr: 2016
• Jahr: 8 July 2016
• Umfang: 8 S.
• Fussnoten: Gesehen am 31.07.2019
• Titel Quelle: Enthalten in: Strahlentherapie und Onkologie
• Ort Quelle: Berlin : Springer Medizin, 1997
• Jahr Quelle: 2016
• Band/Heft Quelle: 192(2016), 9, Seite 641-648
• ISSN Quelle: 1439-099X
• DOI: doi:10.1007/s00066-016-1013-9
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Deep inspiration breath-hold
• Sach-SW: Lebermetastasen
• Sach-SW: Liver metastases
• Sach-SW: Magnetic resonance imaging
• Sach-SW: Magnetresonanzbildgebung
• Sach-SW: Normal tissue reactions
• Sach-SW: Normalgewebereaktionen
• Sach-SW: Stereotactic body radiation therapy
• Sach-SW: Stereotaktische Körperbestrahlungstherapie
• Sach-SW: Tiefer Atemanhalt
• K10plus-PPN: 1670344975

Abstract

AimCT morphologic and histopathologic alterations have been reported after SBRT. We analyzed the correlation of MRI morphologic alterations with radiation doses to assess the potential for MRI-based dose-effect correlation in healthy liver tissue.Patients and methodsMRI data of 24 patients with liver metastases 7±3 weeks after image-guided SBRT in deep-inspiration breath-hold were retrospectively analyzed. MRI images were intermodally matched to the planning CT and corresponding dose distribution. Absolute doses were converted to EQD2,α/β =x with α/β values of 2, 3 for healthy liver tissue, 8 Gy for modelled predamaged liver tissue and 10 Gy for tumor tissue.ResultsA central nonenhancing area was observed within the isodose lines of nominally 48.2 ± 15.2 Gy, EQD2Gy/α/β =10 92.5 ± 27.7 Gy. Contrast-enhancement around the central nonenhancing area was observed within the isodose lines of nominally 46.9 ± 15.3 Gy, EQD2Gy/α/β =10 90.5 ± 28.3 Gy. Outside the high-dose volume, in the beam path, characteristic sharply defined, nonblurred MRI morphologic alterations were observed that corresponded with the following isodose lines: T1-intensity changes occurred at isodose lines of nominally 21.9 ± 6.7 Gy (EQD2,α/β =2 42.5 ± 8.7 Gy, EQD2,α/β =3 38.5 ± 7.6 Gy, EQD2,α/β =8 30.2 ±6.3 Gy). T2-hyper/hypointensity was observed within isodose lines of nominally 22.4 ± 6.6 Gy (EQD2,α/β=2 42.7 ± 8.1 Gy, EQD2,α/β=3 38.7 ± 7 Gy; EQD2,α/β=8 30.5 ± 5.9 Gy).ConclusionsUsing deformable matching, direct spatial/dosimetric correlation of SBRT-induced changes in liver tissue was possible. In the PTV high-dose region, a central nonenhancing area and peripheral contrast medium accumulation was observed. Beam path doses of 38-42 Gy (EQD2,α/β =2-3) induce characteristic MRI morphologic alterations.