Status: Bibliographieeintrag
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| Verfasst von: | Straßburger, Katrin [VerfasserIn]  |
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| | Kang, Evangeline [VerfasserIn] |
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| | Teleman, Aurelio A. [VerfasserIn] |
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| Titel: | Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability |
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| Verf.angabe: | Katrin Strassburger, Evangeline Kang, Aurelio A. Teleman |
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| E-Jahr: | 2019 |
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| Jahr: | February 8, 2019 |
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| Umfang: | 19 S. |
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| Fussnoten: | Gesehen am 02.08.2019 |
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| Titel Quelle: | Enthalten in: PLOS ONE |
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| Ort Quelle: | San Francisco, California, US : PLOS, 2006 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 14(2019, 2) Artikel-Nummer e0198149, 19 Seiten |
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| ISSN Quelle: | 1932-6203 |
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| Abstract: | Palmitoylation is an important posttranslational modification regulating diverse cellular functions. Consequently, aberrant palmitoylation can lead to diseases such as neuronal disorders or cancer. In humans there are roughly one hundred times more palmitoylated proteins than enzymes catalyzing palmitoylation (palmitoyltransferases). Therefore, it is an important challenge to establish the links between palmitoyltransferases and their targets. From publicly available data, we find that expression of human ZDHHC8 correlates significantly with cancer survival. To elucidate the organismal function of ZDHHC8, we study the Drosophila ortholog of hZDHHC8, CG34449/dZDHHC8. Knockdown of dZDHHC8 causes tissue overgrowth while dZDHHC8 mutants are larval lethal. We provide a list of 159 palmitoylated proteins in Drosophila and present data suggesting that scribble and Ras64B are targets of dZDHHC8. |
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| DOI: | doi:10.1371/journal.pone.0198149 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0198149 |
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| | Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0198149 |
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| | DOI: https://doi.org/10.1371/journal.pone.0198149 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Cloning |
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| | Cysteine |
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| | Drosophila melanogaster |
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| | Immunostaining |
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| | Invertebrate genomics |
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| | Larvae |
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| | Palmitoylation |
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| | RNA interference |
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| K10plus-PPN: | 1670501426 |
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| Verknüpfungen: | → Zeitschrift |
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Drosophila ZDHHC8 palmitoylates scribble and Ras64B and controls growth and viability / Straßburger, Katrin [VerfasserIn]; February 8, 2019 (Online-Ressource)
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