TelNet - a database for human and yeast genes involved in telomere maintenance

• Verfasst von: Braun, Delia [VerfasserIn]
• Verfasst von: Chung, Inn [VerfasserIn]
• Verfasst von: Kepper, Nick [VerfasserIn]
• Verfasst von: Deeg, Katharina [VerfasserIn]
• Verfasst von: Rippe, Karsten [VerfasserIn]
• Titel: TelNet - a database for human and yeast genes involved in telomere maintenance
• Verf.angabe: Delia M. Braun, Inn Chung, Nick Kepper, Katharina I. Deeg and Karsten Rippe
• Jahr: 2018
• Umfang: 10 S.
• Fussnoten: Gesehen am 05.08.2019
• Titel Quelle: Enthalten in: BMC genetics
• Ort Quelle: London : BioMed Central, 2000
• Jahr Quelle: 2018
• Band/Heft Quelle: 19(2018,1) Artikel-Nummer 32, 10 Seiten
• ISSN Quelle: 1471-2156
• DOI: doi:10.1186/s12863-018-0617-8
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1670556093

Abstract

The ends of linear chromosomes, the telomeres, comprise repetitive DNA sequences in complex with proteins that protects them from being processed by the DNA repair machinery. Cancer cells need to counteract the shortening of telomere repeats during replication for their unlimited proliferation by reactivating the reverse transcriptase telomerase or by using the alternative lengthening of telomeres (ALT) pathway. The different telomere maintenance (TM) mechanisms appear to involve hundreds of proteins but their telomere repeat length related activities are only partly understood. Currently, a database that integrates information on TM relevant genes is missing.