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Status: Bibliographieeintrag

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Verfasst von:Thierauf, Julia [VerfasserIn]   i
 Affolter, Annette [VerfasserIn]   i
 Laureano, Natalia K. [VerfasserIn]   i
 Plinkert, Peter K. [VerfasserIn]   i
 Heß, Jochen [VerfasserIn]   i
Titel:Low SOX2 expression marks a distinct subset of adenoid cystic carcinoma of the head and neck and is associated with an advanced tumor stage
Verf.angabe:Julia Thierauf, Stephanie E. Weissinger, Johannes A. Veit, Annette Affolter, Natalia K. Laureano, Dirk Beutner, Gregor Heiduschka, Lorenz Kadletz, Moritz Meyer, Alexander Quaas, Peter Plinkert, Thomas K. Hoffmann, Jochen Hess
E-Jahr:2018
Jahr:March 29, 2018
Umfang:11 S.
Fussnoten:Gesehen am 06.08.2019
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2018
Band/Heft Quelle:13 (2018,3) Artikel-Nummer e0194989, 13 Seiten
ISSN Quelle:1932-6203
Abstract:Introduction The transcription factor SOX2 has been identified as a lineage survival oncogene in squamous cell carcinoma and copy number gain is a common event in several human malignancies including head and neck cancer. However, the regulation and function of SOX2 during carcinogenesis as well as its prognostic value appears to be highly context dependent. As an example, high SOX2 expression in lung squamous cell carcinoma (SCC) is related to a favorable prognosis, while it is associated with poor outcome in lung adenocarcinoma. More recently, higher SOX2 levels and improved survival was also reported for head and neck SCC (HNSCC), and silencing of SOX2 expression in HNSCC cell lines revealed a mesenchymal-like phenotype with prominent vimentin expression. So far, SOX2 expression and its clinical relevance for other head and neck cancers, such as adenoid cystic carcinoma (HNACC) have not been sufficiently investigated. Material and methods SOX2, vimentin and E-cadherin expression was assessed by immunohistochemical staining on serial sections from formalin fixed and paraffin embedded tissue samples of a patient cohort (n = 45) with primary ACC and correlated with patient and tumor characteristics as well as survival. Results High SOX2 expression was found in 14 (31%) primary tumor specimens and was significantly correlated with a N0 lymph node status (p = 0.04), while low SOX2 expression was correlated with a solid growth pattern (p = 0.031). Of the 45 patients, 27 tumor samples resembled an EMT-like phenotype, as assessed by high vimentin and low E-cadherin levels. However, in HNACC SOX2 levels were neither correlated with vimentin nor with E-cadherin expression, further supporting a context dependent regulation and function of SOX2 in distinct tumor entities. Conclusion The absence of SOX2 was predominantly found in solid HNACC, which are characterized by a more aggressive phenotype in ACC. However, the underlying molecular mechanisms of SOX2 regulation and function in distinct HNACC subgroups remain to be fully elucidated.
DOI:doi:10.1371/journal.pone.0194989
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1371/journal.pone.0194989
 Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0194989
 DOI: https://doi.org/10.1371/journal.pone.0194989
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Carcinogenesis
 Carcinomas
 Head and neck squamous cell carcinoma
 Lung and intrathoracic tumors
 Lymph nodes
 Metastasis
 Squamous cell lung carcinoma
 Vimentin
K10plus-PPN:1670623440
Verknüpfungen:→ Zeitschrift

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