| Online-Ressource |
Verfasst von: | Brehmer, Stefanie [VerfasserIn]  |
| Clausen, Sven [VerfasserIn]  |
| Schneider, Frank [VerfasserIn]  |
| Schulte, Dirk Michael [VerfasserIn]  |
| Bludau, Frederic [VerfasserIn]  |
| Glatting, Gerhard [VerfasserIn]  |
| Marx, Alexander [VerfasserIn]  |
| Schmiedek, Peter [VerfasserIn]  |
| Hesser, Jürgen [VerfasserIn]  |
| Wenz, Frederik [VerfasserIn]  |
| Giordano, Frank Anton [VerfasserIn]  |
Titel: | Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme |
Verf.angabe: | Stefanie Brehmer, Christian V. Guthier, Sven Clausen, Frank Schneider, Dirk-Michael Schulte, Matthias Benker, Frederic Bludau, Gerhard Glatting, Alexander Marx, Peter Schmiedek, Jürgen Hesser, Frederik Wenz, Frank A. Giordano |
Jahr: | 2018 |
Umfang: | 7 S. |
Fussnoten: | Article first published online: January 15, 2016 ; Gesehen am 06.08.2019 |
Titel Quelle: | Enthalten in: The journal of neurosurgical sciences |
Ort Quelle: | Torino : Ed. Minerva Medica, 1998 |
Jahr Quelle: | 2018 |
Band/Heft Quelle: | 62(2018), 2, Seite 214-220 |
ISSN Quelle: | 1827-1855 |
Abstract: | Patients diagnosed with glioblastoma multiforme receiving stereotactic biopsy only either due to tumor localization or impaired clinical status face a devastating prognosis with very short survival times. One strategy to provide an initial cytoreductive and palliative therapy at the time of the stereotactic biopsy is interstitial irradiation through the pre-defined trajectory of the biopsy channel. We designed a novel treatment planning system and evaluated the treatment potential of a fixed-source and a stepping-source algorithm for interstitial radiosurgery on non-spherical glioblastoma in direct adjacency to risk structures. Using both setups, we show that radiation doses delivered to 100% of the gross tumor volume shifts from sub-therapeutic (10-12 Gy) to sterilizing single doses (25-30 Gy) when using the stepping source algorithm due to improved sparing of organs-at-risk. Specifically, the maximum doses at the brain stem were 100% of the PTV dose when a fixed central source and 38% when a stepping-source algorithm was used. We also demonstrated precision of intracranial target points and stability of superficial and deep trajectories using both a phantom and a body donor study. Our setup now for the first time provides a basis for a clinical proof-of-concept trial and may widen palliation options for patients with limited life expectancy that should not undergo time-consuming therapies. |
DOI: | doi:10.23736/S0390-5616.16.03547-X |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.23736/S0390-5616.16.03547-X |
| Volltext: https://www.minervamedica.it/en/journals/neurosurgical-sciences/article.php?cod=R38Y2018N02A0214 |
| DOI: https://doi.org/10.23736/S0390-5616.16.03547-X |
Datenträger: | Online-Ressource |
Sprache: | eng |
K10plus-PPN: | 1670665690 |
Verknüpfungen: | → Zeitschrift |
Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme / Brehmer, Stefanie [VerfasserIn]; 2018 (Online-Ressource)