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Status: Bibliographieeintrag

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Verfasst von:Brehmer, Stefanie [VerfasserIn]   i
 Clausen, Sven [VerfasserIn]   i
 Schneider, Frank [VerfasserIn]   i
 Schulte, Dirk Michael [VerfasserIn]   i
 Bludau, Frederic [VerfasserIn]   i
 Glatting, Gerhard [VerfasserIn]   i
 Marx, Alexander [VerfasserIn]   i
 Schmiedek, Peter [VerfasserIn]   i
 Hesser, Jürgen [VerfasserIn]   i
 Wenz, Frederik [VerfasserIn]   i
 Giordano, Frank Anton [VerfasserIn]   i
Titel:Combined stereotactic biopsy and stepping-source interstitial irradiation of glioblastoma multiforme
Verf.angabe:Stefanie Brehmer, Christian V. Guthier, Sven Clausen, Frank Schneider, Dirk-Michael Schulte, Matthias Benker, Frederic Bludau, Gerhard Glatting, Alexander Marx, Peter Schmiedek, Jürgen Hesser, Frederik Wenz, Frank A. Giordano
Jahr:2018
Umfang:7 S.
Fussnoten:Article first published online: January 15, 2016 ; Gesehen am 06.08.2019
Titel Quelle:Enthalten in: The journal of neurosurgical sciences
Ort Quelle:Torino : Ed. Minerva Medica, 1998
Jahr Quelle:2018
Band/Heft Quelle:62(2018), 2, Seite 214-220
ISSN Quelle:1827-1855
Abstract:Patients diagnosed with glioblastoma multiforme receiving stereotactic biopsy only either due to tumor localization or impaired clinical status face a devastating prognosis with very short survival times. One strategy to provide an initial cytoreductive and palliative therapy at the time of the stereotactic biopsy is interstitial irradiation through the pre-defined trajectory of the biopsy channel. We designed a novel treatment planning system and evaluated the treatment potential of a fixed-source and a stepping-source algorithm for interstitial radiosurgery on non-spherical glioblastoma in direct adjacency to risk structures. Using both setups, we show that radiation doses delivered to 100% of the gross tumor volume shifts from sub-therapeutic (10-12 Gy) to sterilizing single doses (25-30 Gy) when using the stepping source algorithm due to improved sparing of organs-at-risk. Specifically, the maximum doses at the brain stem were 100% of the PTV dose when a fixed central source and 38% when a stepping-source algorithm was used. We also demonstrated precision of intracranial target points and stability of superficial and deep trajectories using both a phantom and a body donor study. Our setup now for the first time provides a basis for a clinical proof-of-concept trial and may widen palliation options for patients with limited life expectancy that should not undergo time-consuming therapies.
DOI:doi:10.23736/S0390-5616.16.03547-X
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.23736/S0390-5616.16.03547-X
 Volltext: https://www.minervamedica.it/en/journals/neurosurgical-sciences/article.php?cod=R38Y2018N02A0214
 DOI: https://doi.org/10.23736/S0390-5616.16.03547-X
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1670665690
Verknüpfungen:→ Zeitschrift

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