Dual-contrast pCASL using simultaneous gradient-echo/spin-echo multiband EPI

• Verfasst von: Zhang, Ke [VerfasserIn]
• Verfasst von: Sturm, Volker Jörg Friedrich [VerfasserIn]
• Verfasst von: Buschle, Lukas R. [VerfasserIn]
• Verfasst von: Hahn, Artur [VerfasserIn]
• Verfasst von: Bendszus, Martin [VerfasserIn]
• Verfasst von: Heiland, Sabine [VerfasserIn]
• Verfasst von: Schlemmer, Heinz-Peter [VerfasserIn]
• Verfasst von: Ziener, Christian H. [VerfasserIn]
• Verfasst von: Kurz, Felix T. [VerfasserIn]
• Titel: Dual-contrast pCASL using simultaneous gradient-echo/spin-echo multiband EPI
• Verf.angabe: Ke Zhang, Volker J. Sturm, Lukas R. Buschle, Artur Hahn, Seong Dae Yun, N. Jon Shah, Martin Bendszus, Sabine Heiland, Heinz-Peter Schlemmer, Christian H. Ziener, Felix T. Kurz
• Jahr: 2019
• Jahr des Originals: 2018
• Umfang: 9 S.
• Fussnoten: Available online 27 November 2018 ; Gesehen am 30.03.2020
• Titel Quelle: Enthalten in: Magnetic resonance imaging
• Ort Quelle: Amsterdam [u.a.] : Elsevier Science, 1982
• Jahr Quelle: 2019
• Band/Heft Quelle: 57(2019), Seite 359-367
• ISSN Quelle: 1873-5894
• DOI: doi:10.1016/j.mri.2018.11.018
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Arterial spin labeling
• Sach-SW: Gradient-echo/spin-echo EPI
• Sach-SW: Multiband
• Sach-SW: Pseudo-continuous ASL
• Sach-SW: Simultaneous multislice acquisition
• K10plus-PPN: 1670703401

Abstract

A 2D gradient-echo EPI is commonly employed for arterial spin labeling (ASL) readout to achieve fast whole brain coverage measurements. However, such a readout suffers from susceptibility artifacts induced by magnetic field inhomogeneities. To reduce these susceptibility effects, single-shot spin-echo EPI was proposed to be used for acquisitions in continuous ASL (CASL). To minimize functional and physiological variations, a gradient-echo (GE)/spin-echo (SE) dual-echo EPI readout of the CASL sequence is needed for a comparison between GE- and SE-based determination of cerebral blood flow (CBF). In this study, we employed a simultaneous GE/SE multiband EPI as the readout of a pseudo-CASL (pCASL) sequence. Motor cortex activations derived from a finger-tapping task and functional networks from resting state fMRI were compared for both GE and SE contrasts. Direct comparison of SE and GE contrasts revealed that GE ASL provides an improved sensitivity of functional activity in finger-tapping and in resting-state imaging. SE ASL, on the other hand, suffered less from susceptibility artifacts induced by magnetic field inhomogeneities and pulsatile flow artifacts.