Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Schenk, Alexander [VerfasserIn]   i
 Zimmer, Philipp [VerfasserIn]   i
Titel:Acute exercise increases the expression of KIR2DS4 by promoter demethylation in NK cells
Verf.angabe:Alexander Schenk, Walter Pulverer, Christine Koliamitra, Claus Juergen Bauer, Suzana Ilic, Rudolf Heer, Robert Schier, Volker Schick, Bernd W. Böttiger, Clarissa Gerhäuser, Wilhelm Bloch, Philipp Zimmer
Jahr:2019
Jahr des Originals:2018
Umfang:9 S.
Fussnoten:Published online: 3.12.2018 ; Gesehen am 07.08.2019
Titel Quelle:Enthalten in: International journal of sports medicine
Ort Quelle:Stuttgart [u.a.] : Thieme, 1980
Jahr Quelle:2019
Band/Heft Quelle:40(2019), 01, Seite 62-70
ISSN Quelle:1439-3964
Abstract:Positive effects of exercise on cancer prevention and progression have been proposed to be mediated by stimulating natural killer (NK) cells. Because NK cell receptors are regulated by epigenetic modifications, we investigated whether acute aerobic exercise and training change promoter DNA methylation and gene expression of the activating <i>KIR2DS4</i> and the inhibiting <i>KIR3DL1</i> gene. Sixteen healthy women (50-60 years) performed a graded exercise test (GXT) and were randomized into either a passive control group or an intervention group performing a four-week endurance exercise intervention. Blood samples (pre-, post-GXT and post-training) were used for isolation of DNA/RNA of NK cells to assess DNA promoter methylation by targeted deep-amplicon sequencing and gene expression by qRT-PCR. Potential changes in NK cell subsets were determined by flow cytometry. Acute and chronic exercise did not provoke significant alterations of NK cell proportions. Promoter methylation decreased and gene expression increased for <i>KIR2DS4</i> after acute exercise. A high gene expression correlated with a low methylation of CpGs that were altered by acute exercise. Chronic exercise resulted in a minor decrease of DNA methylation and did not alter gene expression. Acute exercise provokes epigenetic modifications, affecting the balance between the activating <i>KIR2DS4</i> and the inhibiting <i>KIR3DL1</i>, with potential benefits on NK cell function.
DOI:doi:10.1055/a-0741-7001
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1055/a-0741-7001
 Volltext: http://www.thieme-connect.de/DOI/DOI?10.1055/a-0741-7001
 DOI: https://doi.org/10.1055/a-0741-7001
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1670716805
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68417535   QR-Code
zum Seitenanfang