Spatiotemporal evolution of venous narrowing in acute MS lesions

• Verfasst von: Eisele, Philipp [VerfasserIn]
• Verfasst von: Szabo, Kristina [VerfasserIn]
• Verfasst von: Ebert, Anne [VerfasserIn]
• Verfasst von: Platten, Michael [VerfasserIn]
• Verfasst von: Gass, Achim [VerfasserIn]
• Titel: Spatiotemporal evolution of venous narrowing in acute MS lesions
• Verf.angabe: Philipp Eisele, Kristina Szabo, Anne Ebert, Wolfgang Brueck, Michael Platten, and Achim Gass
• E-Jahr: 2018
• Jahr: January 18, 2018
• Fussnoten: Gesehen am 08.08.2019
• Titel Quelle: Enthalten in: Neurology: Neuroimmunology & Neuroinflammation ; official journal of the American Academy of Neurology
• Ort Quelle: Philadelphia, Pa. : Wolters Kluwer, 2014
• Jahr Quelle: 2018
• Band/Heft Quelle: 5(2018,2) Artikel-Nummer e440, 8 Seiten
• ISSN Quelle: 2332-7812
• DOI: doi:10.1212/NXI.0000000000000440
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1670864952

Abstract

Objective To investigate the spatiotemporal evolution of venous narrowing in newly developing MS lesions in a longitudinal MRI study including susceptibility-weighted images (SWIs). - Methods We retrospectively investigated serial MR examinations of 18 patients with MS acquired on a 3T MRI system including SWI for acute contrast-enhancing lesions with at least 1 MRI examination before contrast enhancement. The mean diameter of veins at the time point of contrast enhancement was compared with the mean diameter of veins before and after contrast enhancement. - Results A total of 40 acute contrast-enhancing lesions with a corresponding intralesional central vein were included in the study. The mean diameter of intralesional veins at the time of contrast enhancement (0.80 ± 0.12 mm) was smaller than that at before (1.16 ± 0.19 mm) and after contrast enhancement (1.07 ± 0.15 mm; p < 0.001 for all comparisons). - Conclusions Our findings contribute to the increasing database of plaque development and evolution. The smaller diameter of intralesional veins on SWI at the time of blood-brain barrier breakdown may reflect morphologic changes because of perivascular inflammation and/or decreased levels of deoxygenated hemoglobin.