Pathogenese der Psoriasis vulgaris

• Verfasst von: Schäkel, Knut [VerfasserIn]
• Verfasst von: Schön, Michael [VerfasserIn]
• Verfasst von: Ghoreschi, Kamran [VerfasserIn]
• Titel: Pathogenese der Psoriasis vulgaris
• Verf.angabe: K. Schäkel, M.P. Schön, K. Ghoreschi
• E-Jahr: 2016
• Jahr: 31. Mai 2016
• Umfang: 10 S.
• Fussnoten: Gesehen am 08.08.2019
• Titel Quelle: Enthalten in: Der Hautarzt
• Ort Quelle: Berlin : Springer, 1994
• Jahr Quelle: 2016
• Band/Heft Quelle: 67(2016), 6, Seite 422-431
• ISSN Quelle: 1432-1173
• DOI: doi:10.1007/s00105-016-3800-8
• Datenträger: Online-Ressource
• Sprache: ger
• Sach-SW: Autoimmune diseases
• Sach-SW: Autoimmunkrankheit
• Sach-SW: Entzündung
• Sach-SW: Haut
• Sach-SW: IL‑23
• Sach-SW: Inflammation
• Sach-SW: Skin
• Sach-SW: Th17
• K10plus-PPN: 1671027051

Abstract

Psoriasis is an inflammatory T cell-mediated autoimmune disease of skin and joints that affects 2-4 % of the adult population and 0.1-1 % of children. Genetic susceptibility, environmental triggering factors, and innate immune processes initiate psoriasis pathogenesis that results in an adaptive autoreactive response. The T cell response is orchestrated by CD 8+ T cells in the epidermis and by CD 4+ T cells in the dermis that predominantly produce interleukin-17 (IL‑17). Research of the past 15 years unraveled cellular and molecular mechanisms as well as cytokines like TNF-α or IL‑23 that contribute to psoriatic inflammation. This knowledge has been translated into clinical practice and a number of antipsoriatic small molecules and immunobiologics are now available. Here, we discuss the current principles of psoriasis pathogenesis in the context of modern therapies.