Electrochemical effects after transarterial chemoembolization in combination with percutaneous irreversible electroporation

• Verfasst von: Vollherbst, Dominik [VerfasserIn]
• Verfasst von: Bertheau, Robert [VerfasserIn]
• Verfasst von: Fritz, Stefan [VerfasserIn]
• Verfasst von: Mogler, Carolin [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Ryschich, Eduard [VerfasserIn]
• Verfasst von: Radeleff, Boris [VerfasserIn]
• Verfasst von: Sommer, Christof-Matthias [VerfasserIn]
• Titel: Electrochemical effects after transarterial chemoembolization in combination with percutaneous irreversible electroporation
• Titelzusatz: observations in an acute porcine liver model
• Verf.angabe: Dominik Vollherbst, MD, Robert C. Bertheau, MD, Stefan Fritz, MD, Carolin Mogler, MD, Hans-Ulrich Kauczor, MD, Eduard Ryschich, MD, Boris A. Radeleff, MD, Philippe L. Pereira, MD, and Christof M. Sommer, MD
• E-Jahr: 2016
• Jahr: 18 April 2016
• Umfang: 11 S.
• Fussnoten: Gesehen am 09.08.2019
• Titel Quelle: Enthalten in: Journal of vascular and interventional radiology
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1990
• Jahr Quelle: 2016
• Band/Heft Quelle: 27(2016), 6, Seite 913-921.e2
• ISSN Quelle: 1535-7732
• DOI: doi:10.1016/j.jvir.2016.02.001
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1671094972

Abstract

Purpose - To evaluate the effects of combined use of transarterial chemoembolization and irreversible electroporation (IRE) for focal tissue ablation in an acute porcine liver model. - Materials and Methods - Two established interventional techniques were combined: IRE with zones of irreversible and reversible electroporation and chemoembolization with microspheres, iodized oil, and doxorubicin. IRE was performed before chemoembolization in two pigs (pigs 1 and 2; IRE/chemoembolization group), chemoembolization was performed before IRE in two pigs (pigs 3 and 4; chemoembolization/IRE group), and only IRE was performed in two pigs (pigs 5 and 6). Five study groups were defined: IRE/chemoembolization (pigs 1 and 2), chemoembolization/IRE (pigs 3 and 4), IRE only (pigs 5 and 6), chemoembolization only (tissue outside the IRE zones in pigs 1-4), and control (untreated liver tissue outside the IRE zones in pigs 5 and 6). Animals were euthanized 2 hours after intervention. Size and shape of IRE zones on contrast-enhanced computed tomography, cell death on light microscopy, and doxorubicin tissue concentrations on chromatography and fluorescence microscopy were analyzed. - Results - Size and shape of IRE zones were not significantly different (eg, P = .067 for volume). A histologic marker for irreversible cell death was positive in IRE/chemoembolization, chemoembolization/IRE, and IRE groups only in the macroscopically visible IRE zones. Doxorubicin tissue concentrations were not significantly different (P = .873). However, in the reversible electroporation (RE) zones, broad areas with intense intranuclear doxorubicin accumulation were observed in IRE/chemoembolization but not in chemoembolization/IRE and chemoembolization groups. - Conclusions - IRE before chemoembolization enhances the intranuclear accumulation of doxorubicin in the RE zone.