| |  Online-Ressource |
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| Verfasst von: | Lang, Nina [VerfasserIn]  |
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| | Dick, Julika [VerfasserIn] |
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| | Slynko, Alla [VerfasserIn] |
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| | Schulz, Carsten [VerfasserIn] |
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| | Dimitrakopoulou-Strauss, Antonia [VerfasserIn] |
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| | Sachpekidis, Christos [VerfasserIn] |
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| | Enk, Alexander [VerfasserIn] |
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| | Hassel, Jessica C. [VerfasserIn] |
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| Titel: | Clinical significance of signs of autoimmune colitis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography of 100 stage-IV melanoma patients |
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| Verf.angabe: | Nina Lang, Julika Dick, Alla Slynko, Carsten Schulz, Antonia Dimitrakopoulou-Strauss, Christos Sachpekidis, Alexander H. Enk & Jessica C. Hassel |
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| E-Jahr: | 2019 |
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| Jahr: | 15 May 2019 |
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| Umfang: | 10 S. |
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| Fussnoten: | Gesehen am 13.08.2019 ; Im Titel ist die Zahl "18" hochgestellt |
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| Titel Quelle: | Enthalten in: Immunotherapy |
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| Ort Quelle: | London : Future Medicine Ltd, 2009 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 11(2019), 8, Seite 667-676 |
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| ISSN Quelle: | 1750-7448 |
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| Abstract: | Aim: Autoimmune colitis is a typical and possible severe side effect among patients treated with ipilimumab. Patients & methods: We prospectively included 100 patients with metastasized melanoma under ipilimumab treatment in a radiological study of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18F-FDG PET-CT). PET evidence of pancolitis ('PET-colitis') was correlated with clinical variables. Results: We observed a significant correlation between PET-colitis and clinically significant diarrhoea, although PET-colitis was more frequent (49 vs 29% of patients, respectively). Neither PET-colitis nor diarrhoea was significantly correlated with response to therapy. Other immune-related adverse events, however, such as hypophysitis and hepatitis were associated with response to therapy and overall survival. Conclusion: Increased 18F-FDG uptake in the colon correlated with clinical symptoms but did not predict clinical outcome to ipilimumab. |
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| DOI: | doi:10.2217/imt-2018-0146 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: http://dx.doi.org/10.2217/imt-2018-0146 |
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| | DOI: https://doi.org/10.2217/imt-2018-0146 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | autoimmune colitis |
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| | checkpoint inhibition |
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| | F-FDG PET-CT |
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| | immune-related adverse events |
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| | immunotherapy |
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| | ipilimumab |
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| | melanoma |
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| | treatment response |
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| K10plus-PPN: | 1671238443 |
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| Verknüpfungen: | → Zeitschrift |
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Clinical significance of signs of autoimmune colitis in 18F-fluorodeoxyglucose positron emission tomography-computed tomography of 100 stage-IV melanoma patients / Lang, Nina [VerfasserIn]; 15 May 2019 (Online-Ressource)
