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Status: Bibliographieeintrag

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Verfasst von:Raap, Ulrike [VerfasserIn]   i
 Schmelz, Martin [VerfasserIn]   i
Titel:Aktuelles zur kutanen Neurobiologie von Pruritus
Verf.angabe:U. Raap, E. Papakonstantinou, M. Metz, U. Lippert, M. Schmelz
E-Jahr:2016
Jahr:29. Juni 2016
Umfang:6 S.
Fussnoten:Gesehen am 13.08.2019
Titel Quelle:Enthalten in: Der Hautarzt
Ort Quelle:Berlin : Springer, 1994
Jahr Quelle:2016
Band/Heft Quelle:67(2016), 8, Seite 595-600
ISSN Quelle:1432-1173
Abstract:The pathogenesis of chronic and acute pruritus is not yet completely understood. Interactions of neurons with resident and nonresident skin cells seem to play an important role in the regulation of pruritus. Neuronal cells which express specific receptors and are capable of releasing neuromediators play an active role in this interaction. Furthermore, released neuromediators can activate immune cells including mast cells and eosinophils, which are increased in the inflammatory infiltrate of many pruritic skin diseases. Mast cells and eosinophils express receptors for neuromediators themselves. In addition, they can release neurotrophins including nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and cytokines including interleukin (IL)-31 which correlate with disease activity in patients with inflammatory skin diseases including atopic dermatitis and induce neuronal outgrowth. In part, a correlation of these mediators has also been described with pruritus. Although the interplay between transient and resident cells in the skin with peripheral nerves, mast cells, and eosinophils plays an important role in the mutual activation, the neurobiological mechanisms that lead to pruritus are not completely clear yet.
DOI:doi:10.1007/s00105-016-3838-7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s00105-016-3838-7
 DOI: https://doi.org/10.1007/s00105-016-3838-7
Datenträger:Online-Ressource
Sprache:ger
Sach-SW:Atopic dermatitis
 Atopische Dermatitis
 Brain-derived neurotrophic factor
 Nerve growth factor
 Neurobiologie
 Neurobiology
 Sensorische Nerven
 Sensory nerves
K10plus-PPN:1671313690
Verknüpfungen:→ Zeitschrift

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