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Verfasst von:Beynon, Christopher [VerfasserIn]   i
 Wei, Shilai [VerfasserIn]   i
 Radbruch, Alexander [VerfasserIn]   i
 Unterberg, Andreas [VerfasserIn]   i
 Kiening, Karl [VerfasserIn]   i
Titel:Preoperative assessment of haemostasis in patients undergoing stereotactic brain biopsy
Verf.angabe:Christopher Beynon, Shilai Wei, Alexander Radbruch, David Capper, Andreas W. Unterberg, Karl L. Kiening
E-Jahr:2018
Jahr:21 April 2018
Umfang:5 S.
Fussnoten:Gesehen am 16.08.2019
Titel Quelle:Enthalten in: Journal of clinical neuroscience
Ort Quelle:Burlington, Mass. : Harcourt, 1994
Jahr Quelle:2018
Band/Heft Quelle:53(2018), Seite 112-116
ISSN Quelle:1532-2653
Abstract:Parenchymal hemorrhage is considered a major risk factor for perioperative morbidity in patients undergoing stereotactic brain biopsy. Studies on patients undergoing surgical procedures have suggested that evaluation of prothrombin time (PT) and activated partial thromboplastin time (aPTT) is of limited value with regard to prevention of haemorrhagic complications. However, this issue has not yet been addressed in patients undergoing stereotactic biopsy of intracranial lesions. We retrospectively analysed the medical records of 159 consecutive patients undergoing stereotactic biopsy of supratentorial intracranial lesions during a three-year period. Laboratory values (PT, aPTT, platelet count) were reviewed as well as clinical characteristics, modalities of surgical treatment, histopathological results and the postoperative course of patients. The overall diagnostic yield was 93.7%. Histopathological examination revealed glioma (WHOoI: 5, WHOoII: 25, WHOoIII: 23, WHOoIV: 65), lymphoma (n=14), inflammation (n=8) and other entities (n=6). Surgery-associated neurological deficits occurred in 7 patients (4.4%) and completely resolved in 6 of these patients. CT-confirmed intracranial hemorrhage occurred in 2 patients (1.3%) and in both cases, histopathological examination revealed glioblastoma. Results of hemostatic parameters (PT: 99+13%, aPTT: 24+3s, platelet count: 274+87103/μL) were within normal range values in all patients and did not correlate with postsurgical morbidity. Standard assessment of haemostasis seems to be of limited value in patients with intracranial lesions undergoing stereotactic biopsy. Further studies regarding the intratumoural vasculature’s impact on the risk of biopsy-related bleeding are necessary.
DOI:doi:10.1016/j.jocn.2018.04.035
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.jocn.2018.04.035
 Volltext: http://www.sciencedirect.com/science/article/pii/S0967586818300730
 DOI: https://doi.org/10.1016/j.jocn.2018.04.035
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Blood coagulation
 Brain neoplasms
 Hemostasis
 Image-guided biopsy
 Magnetic resonance imaging
 Preoperative care
K10plus-PPN:167152537X
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