Cancer stem cells in head and neck squamous cell carcinoma

• Verfasst von: Peitzsch, Claudia [VerfasserIn]
• Titel: Cancer stem cells in head and neck squamous cell carcinoma
• Titelzusatz: identification, characterization and clinical implications
• Verf.angabe: Claudia Peitzsch, Jacqueline Nathansen, Sebastian I. Schniewind, Franziska Schwarz and Anna Dubrovska
• E-Jahr: 2019
• Jahr: 2 May 2019
• Umfang: 24 S.
• Fussnoten: Gesehen am 20.08.2019
• Titel Quelle: Enthalten in: Cancers
• Ort Quelle: Basel : MDPI, 2009
• Jahr Quelle: 2019
• Band/Heft Quelle: 11(2019,5) Artikel-Nummer 616, 24 Seiten
• ISSN Quelle: 2072-6694
• DOI: doi:10.3390/cancers11050616
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: biomarkers
• Sach-SW: cancer stem cells
• Sach-SW: head and neck squamous cell carcinoma
• Sach-SW: HNSCC
• Sach-SW: therapy resistance
• K10plus-PPN: 1671671600

Abstract

Head and neck squamous cell carcinoma (HNSCC) is the sixth most commonly diagnosed cancer worldwide. Despite advances in the treatment management, locally advanced disease has a poor prognosis, with a 5-year survival rate of approximately 50%. The growth of HNSCC is maintained by a population of cancer stem cells (CSCs) which possess unlimited self-renewal potential and induce tumor regrowth if not completely eliminated by therapy. The population of CSCs is not only a promising target for tumor treatment, but also an important biomarker to identify the patients at risk for therapeutic failure and disease progression. This review aims to provide an overview of the recent pre-clinical and clinical studies on the biology and potential therapeutic implications of HNSCC stem cells.