Acute mountain sickness is not related to cerebral blood flow

• Verfasst von: Baumgartner, Ralf W. [VerfasserIn]
• Verfasst von: Spyridopoulos, Ioakim [VerfasserIn]
• Verfasst von: Bärtsch, Peter [VerfasserIn]
• Verfasst von: Maggiorini, Marco [VerfasserIn]
• Verfasst von: Oelz, Oswald [VerfasserIn]
• Titel: Acute mountain sickness is not related to cerebral blood flow
• Titelzusatz: a decompression chamber study
• Verf.angabe: Ralf W. Baumgartner, Ioakim Spyridopoulos, Peter Bärtsch, Marco Maggiorini, and Oswald Oelz
• E-Jahr: 1999
• Jahr: 01 May 1999
• Umfang: 5 S.
• Fussnoten: Gesehen am 27.08.2019
• Titel Quelle: Enthalten in: Journal of applied physiology
• Ort Quelle: Bethesda, Md. : American Physiological Society, 1948
• Jahr Quelle: 1999
• Band/Heft Quelle: 86(1999), 5, Seite 1578-1582
• ISSN Quelle: 1522-1601
• DOI: doi:10.1152/jappl.1999.86.5.1578
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1672170710

Abstract

To evaluate the pathogenetic role of cerebral blood flow (CBF) changes occurring before and during the development of acute mountain sickness (AMS), peak mean middle cerebral artery flow velocities (V¯¯¯MCAV¯MCA<math display="inline" id="ML1" overflow="scroll" altimg="eq-00001.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>) were assessed by transcranial Doppler sonography in 10 subjects at 490-m altitude, and during three 12-min periods immediately (SA1), 3 (SA2), and 6 (SA3) h after decompression to a simulated altitude of 4,559 m. AMS cerebral scores increased from 0.16 ± 0.14 at baseline to 0.44 ± 0.31 at SA1, 1.11 ± 0.88 at SA2(P < 0.05), and 1.43 ± 1.03 at SA3(P < 0.01); correspondingly, three, seven, and eight subjects had AMS. Absolute and relativeV¯¯¯MCAV¯MCA<math display="inline" id="ML2" overflow="scroll" altimg="eq-00002.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math> at simulated altitude, expressed as percentages of low-altitude values (%V¯¯¯MCAV¯MCA<math display="inline" id="ML3" overflow="scroll" altimg="eq-00003.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>), did not correlate with AMS cerebral scores. Average %V¯¯¯MCAV¯MCA<math display="inline" id="ML4" overflow="scroll" altimg="eq-00004.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math> remained unchanged, because %V¯¯¯MCAV¯MCA<math display="inline" id="ML5" overflow="scroll" altimg="eq-00005.gif"><msub><mover accent="true"><mi>V</mi><mo stretchy="true">¯</mo></mover><mrow><mo>MCA</mo></mrow></msub></math>increased in three and remained unchanged or decreased in seven subjects at SA2 and SA3. These results suggest that CBF is not important in the pathogenesis of AMS and shows substantial interindividual differences during the first hours at simulated altitude.