| Online-Ressource |
Verfasst von: | Kreft, Sophia [VerfasserIn]  |
| Gesierich, Anja [VerfasserIn]  |
| Eigentler, Thomas [VerfasserIn]  |
| Franklin, Cindy [VerfasserIn]  |
| Valpione, Sara [VerfasserIn]  |
| Ugurel, Selma [VerfasserIn]  |
| Utikal, Jochen [VerfasserIn]  |
| Haferkamp, Sebastian [VerfasserIn]  |
| Blank, Christian [VerfasserIn]  |
| Larkin, James [VerfasserIn]  |
| Garbe, Claus [VerfasserIn]  |
| Schadendorf, Dirk [VerfasserIn]  |
| Lorigan, Paul [VerfasserIn]  |
| Schilling, Bastian [VerfasserIn]  |
Titel: | Efficacy of PD-1-based immunotherapy after radiologic progression on targeted therapy in stage IV melanoma |
Verf.angabe: | Sophia Kreft, Anja Gesierich, Thomas Eigentler, Cindy Franklin, Sara Valpione, Selma Ugurel, Jochen Utikal, Sebastian Haferkamp, Christian Blank, James Larkin, Claus Garbe, Dirk Schadendorf, Paul Lorigan, Bastian Schilling |
E-Jahr: | 2019 |
Jahr: | 15 June 2019 |
Umfang: | 9 S. |
Fussnoten: | Gesehen am 28.08.2019 |
Titel Quelle: | Enthalten in: European journal of cancer |
Ort Quelle: | Amsterdam [u.a.] : Elsevier, 1992 |
Jahr Quelle: | 2019 |
Band/Heft Quelle: | 116(2019), Seite 207-2154 |
ISSN Quelle: | 1879-0852 |
Abstract: | Objectives - Targeted therapy (TT) is an effective treatment for advanced BRAFV600-mutated melanoma, but most patients eventually acquire resistance and progress. Here, we evaluated the outcome of second-line immune checkpoint blockade (ICB) after progression on dual BRAF and MEK inhibition. - Methods - Patients with metastatic melanoma progressing on combined BRAF + MEK inhibition and receiving second-line ICB between 2015 and 2019 in 9 tertiary referral centres were enrolled. Demographic and clinical data and blood counts of all patients were collected retrospectively. - Results - We identified 99 patients with stage IV melanoma receiving ICB (nivolumab, pembrolizumab [n = 39] or ipilimumab plus nivolumab [n = 60]) after progression on combined TT. The median progression-free survival was similar in the PD-1 and ipilimumab plus nivolumab group (2.6 months [95% confidence interval {CI}, 2.0-3.1] vs. 2.0 [95% CI, 1.4-2.6], p = 0.15). The objective response rate was 18.0% in the PD-1 and 15.0% in the ipilimumab plus nivolumab group (p = 0.70). The disease control rate was 25.7% for monotherapy and 18.3% for combined ICB (p = 0.39). The median overall survival was 8.4 months (95% CI, 5.1-11.7) for patients receiving PD-1 monotherapy and 7.2 months (95% CI, 5.2-9.1) for patients receiving ipilimumab plus nivolumab (p = 0.86). The latter was associated with a higher rate of treatment-related adverse events (AEs). No significant association of laboratory values or clinicopathological characteristics with response to second-line ICB was observed. - Conclusions - PD-1 monotherapy and combined ipilimumab plus nivolumab show similar activity and outcome in patients with melanoma resistant to BRAF + MEK inhibition. However, combined ipilimumab plus nivolumab was associated with a higher rate of treatment-related AEs compared with monotherapy. |
DOI: | doi:10.1016/j.ejca.2019.05.015 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejca.2019.05.015 |
| Volltext: http://www.sciencedirect.com/science/article/pii/S0959804919303181 |
| DOI: https://doi.org/10.1016/j.ejca.2019.05.015 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | Ipilimumab |
| MAPK |
| Melanoma |
| PD-1 |
| Second-line treatment |
K10plus-PPN: | 1672357454 |
Verknüpfungen: | → Zeitschrift |
Efficacy of PD-1-based immunotherapy after radiologic progression on targeted therapy in stage IV melanoma / Kreft, Sophia [VerfasserIn]; 15 June 2019 (Online-Ressource)