Status: Bibliographieeintrag
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| Verfasst von: | Pilz, Maximilian [VerfasserIn]  |
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| | Kunzmann, Kevin [VerfasserIn] |
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| | Herrmann, Carolin [VerfasserIn] |
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| | Rauch, Geraldine [VerfasserIn] |
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| | Kieser, Meinhard [VerfasserIn] |
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| Titel: | A variational approach to optimal two-stage designs |
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| Verf.angabe: | Maximilian Pilz, Kevin Kunzmann, Carolin Herrmann, Geraldine Rauch, Meinhard Kieser |
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| E-Jahr: | 2019 |
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| Jahr: | 01 July 2019 |
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| Umfang: | 13 S. |
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| Fussnoten: | Gesehen am 02.09.2019 |
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| Titel Quelle: | Enthalten in: Statistics in medicine |
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| Ort Quelle: | Chichester [u.a.] : Wiley, 1982 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 38(2019), 21, Seite 4159-4171 |
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| ISSN Quelle: | 1097-0258 |
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| Abstract: | Recalculating the sample size in adaptive two-stage designs is a well-established method to gain flexibility in a clinical trial. Jennison and Turnbull (2015) proposed an “optimal” adaptive two-stage design based on the inverse normal combination test, which minimizes a mixed criterion of expected sample size under the alternative and conditional power. We demonstrate that the use of a combination test is not necessary to control the type one error rate and use variational techniques to develop a general adaptive design that is globally optimal under predefined optimality criteria. This approach yields to more efficient designs and furthermore allows to investigate the efficiency of the inverse normal method and the relation between local (interim-based) recalculation rules and global (unconditional) optimality of adaptive two-stage designs. |
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| DOI: | doi:10.1002/sim.8291 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1002/sim.8291 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/sim.8291 |
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| | DOI: https://doi.org/10.1002/sim.8291 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | adaptive design |
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| | clinical trial |
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| | inverse normal combination test |
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| | optimal design |
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| | sample size calculation |
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| K10plus-PPN: | 1675682275 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ variational approach to optimal two-stage designs / Pilz, Maximilian [VerfasserIn]; 01 July 2019 (Online-Ressource)
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