Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Stojic, Aleksandar [VerfasserIn]   i
 Bojcevski, Jovana [VerfasserIn]   i
 Williams, Sarah K. [VerfasserIn]   i
 Bas Orth, Carlos [VerfasserIn]   i
 Diem, Ricarda [VerfasserIn]   i
 Fairless, Richard [VerfasserIn]   i
Titel:Preclinical stress originates in the rat optic nerve head during development of autoimmune optic neuritis
Verf.angabe:Aleksandar Stojic, Jovana Bojcevski, Sarah K. Williams, Carlos Bas‐Orth, Stefan Nessler, Christopher Linington, Ricarda Diem, Richard Fairless
Jahr:2019
Jahr des Originals:2018
Umfang:13 S.
Teil:volume:67
 year:2019
 number:3
 pages:512-524
 extent:13
Fussnoten:First published: 21 December 2018 ; Gesehen am 02.09.2019
Titel Quelle:Enthalten in: Glia
Ort Quelle:Bognor Regis [u.a.] : Wiley-Liss, 1988
Jahr Quelle:2019
Band/Heft Quelle:67(2019), 3, Seite 512-524
ISSN Quelle:1098-1136
Abstract:Optic neuritis is a common manifestation of multiple sclerosis, an inflammatory demyelinating disease of the CNS. Although it is the presenting symptom in many cases, the initial events are currently unknown. However, in the earliest stages of autoimmune optic neuritis in rats, pathological changes are already apparent such as microglial activation and disturbances in myelin ultrastructure of the optic nerves. αB-crystallin is a heat-shock protein induced in cells undergoing cellular stress and has been reported to be up-regulated in both multiple sclerosis and its animal model, experimental autoimmune encephalomyelitis. Therefore, we wished to investigate the timing and localization of its expression in autoimmune optic neuritis. Although loss of oligodendrocytes was not observed until the later disease stages accompanying immune cell infiltration and demyelination, an increase in oligodendrocyte αB-crystallin was observed during the preclinical stages. This was most pronounced within the optic nerve head and was associated with areas of IgG deposition. Since treatment of isolated oligodendrocytes with sera from myelin oligodendrocyte glycoprotein (MOG)-immunized animals induced an increase in αB-crystallin expression, as did passive transfer of sera from MOG-immunized animals to unimmunized recipients, we propose that the partially permeable blood-brain barrier of the optic nerve head may present an opportunity for blood-borne components such as anti-MOG antibodies to come into contact with oligodendrocytes as one of the earliest events in disease development.
DOI:doi:10.1002/glia.23560
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/glia.23560
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/glia.23560
 DOI: https://doi.org/10.1002/glia.23560
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:auto-antibody
 EAE
 oligodendrocyte
 optic nerve head
 optic neuritis
 αB-crystallin
K10plus-PPN:1675688133
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68425972   QR-Code
zum Seitenanfang