Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience

• Verfasst von: Hadar, Ravit [VerfasserIn]
• Verfasst von: Vollmayr, Barbara [VerfasserIn]
• Titel: Recurrent stress across life may improve cognitive performance in individual rats, suggesting the induction of resilience
• Verf.angabe: Ravit Hadar, Henriette Edemann-Callesen, Elizabeth Barroeta Hlusicka, Franziska Wieske, Martin Vogel, Lydia Günther, Barbara Vollmayr, Rainer Hellweg, Andreas Heinz, Alexander Garthe, Christine Winter
• E-Jahr: 2019
• Jahr: 05 August 2019
• Umfang: 10 S.
• Fussnoten: Gesehen am 05.09.2019
• Titel Quelle: Enthalten in: Translational Psychiatry
• Ort Quelle: London : Nature Publishing Group, 2011
• Jahr Quelle: 2019
• Band/Heft Quelle: 9(2019) Artikel-Nummer 185, 10 Seiten
• ISSN Quelle: 2158-3188
• DOI: doi:10.1038/s41398-019-0523-5
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 167601926X

Abstract

Depressive symptoms are often accompanied by cognitive impairments and recurrent depressive episodes are discussed as a potential risk for dementia. Especially, stressful life events are considered a potent risk factor for depression. Here, we induced recurrent stress-induced depressive episodes over the life span of rats, followed by cognitive assessment in the symptom-free period. Rats exposed to stress-induced depressive episodes learned faster than control rats. A high degree of stress-induced depressive-like behavior early in the paradigm was a predictor of improved cognitive performance, suggesting induction of resilience. Subsequently, exposure to lorazepam prior to stress-induced depressive episodes and cognitive testing in a nonaversive environment prevented the positive effect. This indicates a beneficial effect of the stress-associated situation, with the existence of individual coping abilities. Altogether, stress may in some have a beneficial effect, yet for those individuals unable to tackle these aversive events, consecutive unpleasant episodes may lead to worse cognitive performance later in life.