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| Verfasst von: | Kather, Jakob Nikolas [VerfasserIn]  |
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| | Hörner, Christian [VerfasserIn] |
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| | Weis, Cleo-Aron Thias [VerfasserIn] |
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| | Aung, Thiha [VerfasserIn] |
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| | Vokuhl, Christian [VerfasserIn] |
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| | Weiß, Christel [VerfasserIn] |
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| | Scheer, Monika [VerfasserIn] |
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| | Marx, Alexander [VerfasserIn] |
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| | Simon-Keller, Katja [VerfasserIn] |
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| Titel: | CD163+ immune cell infiltrates and presence of CD54+ microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma |
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| Verf.angabe: | Jakob Nikolas Kather, Christian Hoerner, Cleo-Aron Weis, Thiha Aung, Christian Vokuhl, Christel Weiss, Monika Scheer, Alexander Marx & Katja Simon-Keller |
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| E-Jahr: | 2019 |
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| Jahr: | 25 June 2019 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 10.09.2019 |
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| Titel Quelle: | Enthalten in: Scientific reports |
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| Ort Quelle: | [London] : Springer Nature, 2011 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 9(2019) Artikel-Nummer 9211, 12 Seiten |
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| ISSN Quelle: | 2045-2322 |
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| Abstract: | Rhabdomyosarcomas (RMS) are rare and often lethal diseases. It is assumed that the tumor microenvironment (TME) of RMS exerts an immunosuppressive function, but there is currently no systematic analysis of the immune cells infiltrating sarcoma tissue. Focusing on two common types of RMS (alveolar [RMA] and embryonal [RME]), we performed a comprehensive immunohistochemical analysis of tumor-infiltrating immune cells in the TME. We performed a qualitative estimation of infiltrating immune cells in the tumor microenvironment by an experienced pathologist as well as a quantitative digital pathology analysis. We found that (1) manual and automatic quantification of tumor-infiltrating immune cells were consistent; (2) RME tumors showed a higher degree of immune cell infiltration than RMA tumors but (3) the number of tumor infiltrating lymphocytes was low compared to other solid tumor types; (4) microvascular density correlated with immune cell infiltration and (5) CD163 positive macrophages as well as CD54 positive microvessels were more often detected in RME than in RMA and correlated with patient overall and event free survival. Our systematic analysis provides a comprehensive view of the immune landscape of RMS which needs to be taken into account for developing immunotherapies for this rare type of cancer. |
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| DOI: | doi:10.1038/s41598-019-45551-y |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1038/s41598-019-45551-y |
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| | Volltext: https://www.nature.com/articles/s41598-019-45551 |
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| | DOI: https://doi.org/10.1038/s41598-019-45551-y |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | blockade |
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| | cancer |
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| | classification |
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| | immune-response |
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| | immunotherapy |
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| | ligand 1 expression |
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| | microvessel density |
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| | mutational landscape |
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| | myeloid cells |
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| | soft-tissue sarcoma |
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| K10plus-PPN: | 167637535X |
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| Verknüpfungen: | → Zeitschrift |
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CD163+ immune cell infiltrates and presence of CD54+ microvessels are prognostic markers for patients with embryonal rhabdomyosarcoma / Kather, Jakob Nikolas [VerfasserIn]; 25 June 2019 (Online-Ressource)
