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Verfasst von:Corso, Jasmin [VerfasserIn]   i
 Słabicki, Mikołaj [VerfasserIn]   i
 Hüllein, Jennifer [VerfasserIn]   i
 Zenz, Thorsten [VerfasserIn]   i
Titel:Elucidation of tonic and activated B-cell receptor signaling in Burkitt’s lymphoma provides insights into regulation of cell survival
Verf.angabe:Jasmin Corso, Kuan-Ting Pan, Roland Walter, Carmen Doebele, Sebastian Mohr, Hanibal Bohnenberger, Philipp Ströbel, Christof Lenz, Mikolaj Slabicki, Jennifer Hüllein, Federico Comoglio, Michael A. Rieger, Thorsten Zenz, Jürgen Wienands, Michael Engelke, Hubert Serve, Henning Urlaub, and Thomas Oellerich
E-Jahr:2016
Jahr:May 6, 2016
Umfang:6 S.
Fussnoten:Gesehen am 10.09.2019
Titel Quelle:Enthalten in: National Academy of Sciences (Washington, DC)Proceedings of the National Academy of Sciences of the United States of America
Ort Quelle:Washington, DC : National Acad. of Sciences, 1915
Jahr Quelle:2016
Band/Heft Quelle:113(2016), 20, Seite 5688-5693
ISSN Quelle:1091-6490
Abstract:Burkitt's lymphoma (BL) is a highly proliferative B-cell neoplasm and is treated with intensive chemotherapy that, because of its toxicity, is often not suitable for the elderly or for patients with endemic BL in developing countries. BL cell survival relies on signals transduced by B-cell antigen receptors (BCRs). However, tonic as well as activated BCR signaling networks and their relevance for targeted therapies in BL remain elusive. We have systematically characterized and compared tonic and activated BCR signaling in BL by quantitative phosphoproteomics to identify novel BCR effectors and potential drug targets. We identified and quantified ∼16,000 phospho-sites in BL cells. Among these sites, 909 were related to tonic BCR signaling, whereas 984 phospho-sites were regulated upon BCR engagement. The majority of the identified BCR signaling effectors have not been described in the context of B cells or lymphomas yet. Most of these newly identified BCR effectors are predicted to be involved in the regulation of kinases, transcription, and cytoskeleton dynamics. Although tonic and activated BCR signaling shared a considerable number of effector proteins, we identified distinct phosphorylation events in tonic BCR signaling. We investigated the functional relevance of some newly identified BCR effectors and show that ACTN4 and ARFGEF2, which have been described as regulators of membrane-trafficking and cytoskeleton-related processes, respectively, are crucial for BL cell survival. Thus, this study provides a comprehensive dataset for tonic and activated BCR signaling and identifies effector proteins that may be relevant for BL cell survival and thus may help to develop new BL treatments.
DOI:doi:10.1073/pnas.1601053113
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1073/pnas.1601053113
 Volltext: https://www.pnas.org/content/113/20/5688
 DOI: https://doi.org/10.1073/pnas.1601053113
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:B-cell receptor
 cancer biology
 lymphoma
 phosphoproteome
K10plus-PPN:1676403299
Verknüpfungen:→ Zeitschrift

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