| |  Online-Ressource |
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| Verfasst von: | Yin, Libo [VerfasserIn]  |
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| | Xiao, Xi [VerfasserIn] |
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| | Georgikou, Christina [VerfasserIn] |
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| | Yin, Yefeng [VerfasserIn] |
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| | Liu, Li [VerfasserIn] |
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| | Karakhanova, Svetlana [VerfasserIn] |
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| | Luo, Yiqiao [VerfasserIn] |
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| | Gladkich, Jury [VerfasserIn] |
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| | Fellenberg, Jörg [VerfasserIn] |
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| | Sticht, Carsten [VerfasserIn] |
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| | Gretz, Norbert [VerfasserIn] |
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| | Gross, Wolfgang [VerfasserIn] |
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| | Herr, Ingrid [VerfasserIn] |
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| Titel: | MicroRNA-365a-3p inhibits c-Rel-mediated NF-[kappa] B signaling and the progression of pancreatic cancer |
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| Verf.angabe: | Libo Yin, Xi Xiao, Christina Georgikou, Yefeng Yin, Li Liu, Svetlana Karakhanova, Yiqiao Luo, Jury Gladkich, Joerg Fellenberg, Carsten Sticht, Norbert Gretz, Wolfgang Gross, Ingrid Herr |
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| E-Jahr: | 2019 |
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| Jahr: | 23 March 2019 |
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| Umfang: | 10 S. |
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| Fussnoten: | Im Titel ist "kappa" als griechischer Buchstabe dargestellt ; Gesehen am 12.09.2019 |
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| Titel Quelle: | Enthalten in: Cancer letters |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1975 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 452(2019), Seite 203-212 |
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| ISSN Quelle: | 1872-7980 |
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| Abstract: | NF-κB contributes to the aggressiveness of pancreatic ductal adenocarcinoma (PDA), which is counteracted by the bioactive agent sulforaphane. We investigated sulforaphane-induced microRNA signaling and its influence on progression features. Using established cell lines, microRNA and gene arrays, we predicted miR-365a as the top candidate for the sulforaphane-induced inhibition of the NF-κB subunit c-Rel. The lipofection of miR-365a-3p mimics inhibited the luciferase activity of a c-Rel 3′-UTR construct, as well as c-Rel expression, NF-κB activity, and tumor viability, migration, and clonogenicity, whereas apoptosis was induced. In vivo, miR-365a-3p reduced the volume of tumor xenografts and the expression of progression markers. In a tissue array, the expression of miR-365a-3p was absent in almost all 91 malignant tissues but not in 5 normal tissues, thus confirming the previous results. Our observations suggest that sulforaphane-induced miR-365a-3p expression inhibits NF-κB activity by downregulating c-Rel, which prevents the progression of PDA. |
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| DOI: | doi:10.1016/j.canlet.2019.03.025 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.canlet.2019.03.025 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0304383519301818 |
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| | DOI: https://doi.org/10.1016/j.canlet.2019.03.025 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | microRNA |
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| | NF-κB signaling |
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| | Pancreatic cancer |
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| | Sulforaphane |
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| K10plus-PPN: | 167677128X |
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| Verknüpfungen: | → Zeitschrift |
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MicroRNA-365a-3p inhibits c-Rel-mediated NF-[kappa] B signaling and the progression of pancreatic cancer / Yin, Libo [VerfasserIn]; 23 March 2019 (Online-Ressource)
