| Online-Ressource |
Verfasst von: | Fischer, Christian [VerfasserIn]  |
| Preuß, Eva-Maria [VerfasserIn]  |
| Tanner, Michael Christopher [VerfasserIn]  |
| Bruckner, Thomas [VerfasserIn]  |
| Krix, Martin [VerfasserIn]  |
| Amarteifio, Erick [VerfasserIn]  |
| Miska, Matthias [VerfasserIn]  |
| Moghaddam-Alvandi, Arash [VerfasserIn]  |
| Schmidmaier, Gerhard [VerfasserIn]  |
| Weber, Marc-André [VerfasserIn]  |
Titel: | Dynamic contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging for preoperative diagnosis of infected nonunions |
Verf.angabe: | Christian Fischer, MD, Eva-Maria Preuβ, MD, Michael Tanner, MD, Thomas Bruckner, PhD, Martin Krix, MD, Erick Amarteifio, MD, Matthias Miska, MD, Arash Moghaddam-Alvandi, MD, Gerhard Schmidmaier, MD, Marc-André Weber, MD |
E-Jahr: | 2016 |
Jahr: | 1 April 2016 |
Umfang: | 10 S. |
Fussnoten: | Gesehen am 12.09.2019 |
Titel Quelle: | Enthalten in: Journal of ultrasound in medicine |
Ort Quelle: | Hoboken, NJ : Wiley, 1982 |
Jahr Quelle: | 2016 |
Band/Heft Quelle: | 35(2016), 5, Seite 933-942 |
ISSN Quelle: | 1550-9613 |
Abstract: | Objectives Bone regeneration depends on perfusion of the fracture tissue, whereby hypervascularity is associated with infection, which itself causes nonunions. To date, nonunion perfusion has not been assessed with contrast-enhanced sonography. The aim of this study was to evaluate the potential of contrast-enhanced sonography in the analysis of nonunion tissue perfusion. Methods Nonunion vascularity of 31 patients before revision surgery was prospectively examined with qualitative contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging (MRI). Time-intensity curves from 2-minute contrast-enhanced sonographic video clips were generated, and parameters such as wash-in rate, rise time, and peak enhancement were quantified. On dynamic contrast-enhanced MRI, the initial area under the enhancement curve was quantified. Preoperative radiographs, computed tomograms, the clinical nonunion score, laboratory infection features, as well as contrast-enhanced sonographic and dynamic contrast-enhanced MRI perfusion were correlated with microbiological results from the nonunion tissue. Results Both qualitative and quantitative contrast-enhanced sonography showed significant differences between infected and aseptic nonunions (P = .015 and .020). The qualitative dynamic contrast-enhanced MRI analysis was not significant (P= .244), but after quantification, a strong correlation (P = .007) with microbiological results was noted. A receiver operating characteristic analysis calculated ideal cutoff values for quantitative contrast-enhanced sonography and dynamic contrast-enhanced MRI so that their combination detected infected nonunions with sensitivity and specificity of 88.9% and 77.3%, respectively. Clinical, radiologic, and laboratory examinations did not correlate with microbiological results (P > .05). Conclusions Contrast-enhanced sonography can visualize the vascularity of nonunions in real time, while quantification software allows for a semiobjective evaluation of bone perfusion. The correlations of both quantitative contrast-enhanced sonography and dynamic contrast-enhanced MRI with microbiological results show their high value for differentiation of infected from aseptic nonunions. |
DOI: | doi:10.7863/ultra.15.06107 |
URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.7863/ultra.15.06107 |
| Volltext: https://onlinelibrary.wiley.com/doi/abs/10.7863/ultra.15.06107 |
| DOI: https://doi.org/10.7863/ultra.15.06107 |
Datenträger: | Online-Ressource |
Sprache: | eng |
Sach-SW: | contrast-enhanced sonography |
| dynamic contrast-enhanced magnetic resonance imaging |
| infection |
| musculoskeletal ultrasound |
| nonunion |
| perfusion |
| quantification |
K10plus-PPN: | 1676814272 |
Verknüpfungen: | → Zeitschrift |
Dynamic contrast-enhanced sonography and dynamic contrast-enhanced magnetic resonance imaging for preoperative diagnosis of infected nonunions / Fischer, Christian [VerfasserIn]; 1 April 2016 (Online-Ressource)