| |  Online-Ressource |
|---|
| Verfasst von: | Maida, Adriano [VerfasserIn]  |
|---|
| | Augustin, Hellmut [VerfasserIn] |
|---|
| | Herzig, Stephan [VerfasserIn] |
|---|
| | Rose, Adam J. [VerfasserIn] |
|---|
| Titel: | Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance |
|---|
| Verf.angabe: | Adriano Maida, Annika Zota, Alexandros Vegiopoulos, Sila Appak-Baskoy, Hellmut G. Augustin, Mathias Heikenwalder, Stephan Herzig, Adam J. Rose |
|---|
| E-Jahr: | 2018 |
|---|
| Jahr: | [July 2018] |
|---|
| Umfang: | 8 S. |
|---|
| Illustrationen: | Illustrationen |
|---|
| Fussnoten: | Available online 7 April 2018 ; Gesehen am 17.09.2019 |
|---|
| Titel Quelle: | Enthalten in: The journal of nutritional biochemistry |
|---|
| Ort Quelle: | New York, NY [u.a.] : Elsevier, 1990 |
|---|
| Jahr Quelle: | 2018 |
|---|
| Band/Heft Quelle: | 57(2018), Seite 189-196 |
|---|
| ISSN Quelle: | 1873-4847 |
|---|
| Abstract: | Recent studies have demonstrated that dietary protein dilution (PD) can promote metabolic inefficiency and improve glucose metabolism. However, whether PD can promote other aspects of metabolic health, such as improve systemic lipid metabolism, and mechanisms therein remains unknown. Mouse models of obesity, such as high-fat-diet-fed C57Bl/6 N mice, and New Zealand Obese mice were fed normal (i.e., 20%P) and protein-dilute (i.e., 5%EP) diets. FGF21−/− and Cd36−/− and corresponding littermate +/+ controls were also studied to examine gene-diet interactions. Here, we show that chronic PD retards the development of hypertrigylceridemia and fatty liver in obesity and that this relies on the induction of the hepatokine fibroblast growth factor 21 (FGF21). Furthermore, PD greatly enhances systemic lipid homeostasis, the mechanisms by which include FGF21-stimulated, and cluster of differentiation 36 (CD36) mediated, fatty acid clearance by oxidative tissues, such as heart and brown adipose tissue. Taken together, our preclinical studies demonstrate a novel nutritional strategy, as well as highlight a role for FGF21-stimulated systemic lipid metabolism, in combating obesity-related dyslipidemia. |
|---|
| DOI: | doi:10.1016/j.jnutbio.2018.03.027 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.jnutbio.2018.03.027 |
|---|
| | Volltext: http://www.sciencedirect.com/science/article/pii/S0955286317310227 |
|---|
| | DOI: https://doi.org/10.1016/j.jnutbio.2018.03.027 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| Sach-SW: | Diet |
|---|
| | Fatty liver |
|---|
| | Metabolism |
|---|
| | Nutrition |
|---|
| | Transport |
|---|
| K10plus-PPN: | 1677143215 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
Dietary protein dilution limits dyslipidemia in obesity through FGF21-driven fatty acid clearance / Maida, Adriano [VerfasserIn]; [July 2018] (Online-Ressource)
