| |  Online-Ressource |
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| Verfasst von: | Rusu, Patricia M. [VerfasserIn]  |
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| | Döring, Kristina [VerfasserIn] |
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| | Dettling, Steffen [VerfasserIn] |
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| | Tschaharganeh, Darjus-Felix [VerfasserIn] |
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| | Bukau, Bernd [VerfasserIn] |
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| | Kramer, Günter [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| Titel: | GPD1 specifically marks dormant glioma stem cells with a distinct metabolic profile |
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| Verf.angabe: | Patricia Rusu, Chunxuan Shao, Anna Neuerburg, Azer Aylin Acikgöz, Yonghe Wu, Peng Zou, Prasad Phapale, Tchirupura S. Shankar, Kristina Döring, Steffen Dettling, Huiqin Körkel-Qu, Gözde Bekki, Barbara Costa, Te Guo, Olga Friesen, Magdalena Schlotter, Mathias Heikenwalder, Darjus F. Tschaharganeh, Bernd Bukau, Günter Kramer, Peter Angel, Christel Herold-Mende, Bernhard Radlwimmer, Hai-Kun Liu |
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| E-Jahr: | 2019 |
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| Jahr: | 11 July 2019 |
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| Umfang: | 17 S. |
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| Fussnoten: | Gesehen am 18.09.2019 |
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| Titel Quelle: | Enthalten in: Cell stem cell |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2007 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 25(2019), 2, Seite 241-257 |
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| ISSN Quelle: | 1875-9777 |
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| Abstract: | Summary - Brain tumor stem cells (BTSCs) are a chemoresistant population that can drive tumor growth and relapse, but the lack of BTSC-specific markers prevents selective targeting that spares resident stem cells. Through a ribosome-profiling analysis of mouse neural stem cells (NSCs) and BTSCs, we find glycerol-3-phosphate dehydrogenase 1 (GPD1) expression specifically in BTSCs and not in NSCs. GPD1 expression is present in the dormant BTSC population, which is enriched at tumor borders and drives tumor relapse after chemotherapy. GPD1 inhibition prolongs survival in mouse models of glioblastoma in part through altering cellular metabolism and protein translation, compromising BTSC maintenance. Metabolomic and lipidomic analyses confirm that GPD1+ BTSCs have a profile distinct from that of NSCs, which is dependent on GPD1 expression. Similar GPD1 expression patterns and prognostic associations are observed in human gliomas. This study provides an attractive therapeutic target for treating brain tumors and new insights into mechanisms regulating BTSC dormancy. |
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| DOI: | doi:10.1016/j.stem.2019.06.004 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.stem.2019.06.004 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1934590919302681 |
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| | DOI: https://doi.org/10.1016/j.stem.2019.06.004 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | cancer stem cell |
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| | dormancy |
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| | glioblastoma |
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| | glycerol-3-phosphate dehydrogenase 1 |
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| | mouse model |
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| | ribosome profiling |
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| K10plus-PPN: | 1677244917 |
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| Verknüpfungen: | → Zeitschrift |
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GPD1 specifically marks dormant glioma stem cells with a distinct metabolic profile / Rusu, Patricia M. [VerfasserIn]; 11 July 2019 (Online-Ressource)
