| |  Online-Ressource |
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| Verfasst von: | Korshunov, Andrey [VerfasserIn]  |
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| | Casalini, Belén [VerfasserIn] |
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| | Chavez, Lukas [VerfasserIn] |
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| | Hielscher, Thomas [VerfasserIn] |
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| | Sill, Martin [VerfasserIn] |
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| | Schrimpf, Daniel [VerfasserIn] |
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| | Stichel, Damian [VerfasserIn] |
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| | Capper, David [VerfasserIn] |
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| | Sturm, Dominik [VerfasserIn] |
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| | Lichter, Peter [VerfasserIn] |
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| | Herold-Mende, Christel [VerfasserIn] |
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| | Wick, Wolfgang [VerfasserIn] |
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| | Pfister, Stefan [VerfasserIn] |
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| | Kool, Marcel [VerfasserIn] |
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| | Jones, David T. W. [VerfasserIn] |
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| | Deimling, Andreas von [VerfasserIn] |
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| | Sahm, Felix [VerfasserIn] |
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| Titel: | Integrated molecular characterization of IDH-mutant glioblastomas |
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| Verf.angabe: | A. Korshunov, B. Casalini, L. Chavez, T. Hielscher, M. Sill, M. Ryzhova, T. Sharma, D. Schrimpf, D. Stichel, D. Capper, D.E. Reuss, D. Sturm, O. Absalyamova, A. Golanov, S. Lambo, M. Bewerunge‐Hudler, P. Lichter, C. Herold‐Mende, W. Wick, S.M. Pfister, M. Kool, D.T.W. Jones, A. von Deimling and F. Sahm |
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| Jahr: | 2019 |
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| Umfang: | 11 S. |
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| Fussnoten: | First published: 16 October 2018 ; Gesehen am 18.09.2019 |
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| Titel Quelle: | Enthalten in: Neuropathology & applied neurobiology |
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| Ort Quelle: | Oxford [u.a.] : Wiley-Blackwell, 1975 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 45(2019), 2, Seite 108-118 |
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| ISSN Quelle: | 1365-2990 |
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| Abstract: | Aims: Mutations of isocitrate dehydrogenase (IDH)1/2 affect almost all astrocytomas of WHO grade II and III. A subset of IDH-mutant astrocytic tumours progresses to IDH-mutant glioblastoma or presents with the histology of a glioblastoma at first presentation. We set out here to assess the molecular spectrum of IDH-mutant glioblastomas. Methods: We performed an integrated molecular analysis of a mono-centric cohort (n = 97); assessed through genome-wide DNA methylation analysis, copy-number profiling and targeted next generation sequencing using a neurooncology-tailored gene panel. Results: Of these 97 IDH-mutant glioblastomas, 68 had a glioblastoma at first presentation (‘de novo’ IDH-mutant glioblastoma) and 29 emerged from a prior low-grade lesion (‘evolved’ IDH-mutant glioblastoma). Unsupervised hierarchical clustering of DNA methylation data disclosed that IDH-mutant glioblastoma (‘de novo’ and ‘evolved’) formed a distinct group separate from other diffuse glioma subtypes. Homozygous deletions of CDKN2A/B were found to be associated with shorter survival. Conclusions: This study demonstrates DNA methylation patterns in IDH-mutant glioblastoma to be distinct from lower-grade astrocytic counterparts but homogeneous within de novo and evolved IDH-mutant glioblastomas, and identifies CDKN2A as a marker for possible genetic sub-stratification. |
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| DOI: | doi:10.1111/nan.12523 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1111/nan.12523 |
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| | Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/nan.12523 |
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| | DOI: https://doi.org/10.1111/nan.12523 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CDKN2A |
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| | DNA methylation |
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| | glioblastoma |
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| | glioma |
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| | IDH mutation |
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| K10plus-PPN: | 1677249749 |
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| Verknüpfungen: | → Zeitschrift |
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Integrated molecular characterization of IDH-mutant glioblastomas / Korshunov, Andrey [VerfasserIn]; 2019 (Online-Ressource)
