Is MRCP necessary to diagnose pancreas divisum?

• Verfasst von: Bogveradze, Nino [VerfasserIn]
• Verfasst von: Hasse, Felix [VerfasserIn]
• Verfasst von: Mayer, Philipp [VerfasserIn]
• Verfasst von: Rupp, Christian [VerfasserIn]
• Verfasst von: Tjaden, Christin [VerfasserIn]
• Verfasst von: Klauß, Miriam [VerfasserIn]
• Verfasst von: Kauczor, Hans-Ulrich [VerfasserIn]
• Verfasst von: Weber, Tim [VerfasserIn]
• Titel: Is MRCP necessary to diagnose pancreas divisum?
• Verf.angabe: Nino Bogveradze, Felix Hasse, Philipp Mayer, Christian Rupp, Christin Tjaden, Miriam Klauss, Hans-Ulrich Kauczor and Tim Frederik Weber
• E-Jahr: 2019
• Jahr: 29 April 2019
• Umfang: 7 S.
• Fussnoten: Gesehen am 20.09.2019
• Titel Quelle: Enthalten in: BMC medical imaging
• Ort Quelle: London : BioMed Central, 2001
• Jahr Quelle: 2019
• Band/Heft Quelle: 19(2019), Artikel-ID 33, Seite 1-7
• ISSN Quelle: 1471-2342
• DOI: doi:10.1186/s12880-019-0329-1
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: HASTE
• Sach-SW: MRCP
• Sach-SW: MRI
• Sach-SW: Pancreas divisum
• Sach-SW: TIRM
• K10plus-PPN: 1677417900
• K10plus-PPN:
  Universitätsbibliothek
• Lokale URL UB: Zum Volltext

Abstract

Background: The purpose of this study is to compare the performance of three-dimensional magnetic resonance cholangiopancreatography (3D-MRCP) with non-MRCP T2-weighted magnetic resonance imaging (MRI) sequences for diagnosis of pancreas divisum (PD). Methods: This is a retrospective study of 342 consecutive patients with abdominal MRI including 3D-MRCP. 3D-MRCP was a coronal respiration-navigated T2-weighted sequence with 1.5 mm slice thickness. Non-MRCP T2-weighted sequences were (1) a coronal inversion recovery sequence (TIRM) with 6 mm slice thickness and (2) a transverse single shot turbo spin echo sequence (HASTE) with 4 mm slice thickness. For 3D-MRCP, TIRM, and HASTE, presence of PD and assessment of evaluability were determined in a randomized manner. A consensus read by two radiologists using 3D-MRCP, non-MRCP T2-weighted sequences, and other available imaging sequences served as reference standard for diagnosis of PD. Statistical analysis included performance analysis of 3D-MRCP, TIRM, and HASTE and testing for noninferiority of non-MRCP T2-weighted sequences compared with 3D-MRCP. Results: Thirty-three of 342 patients (9.7%) were diagnosed with PD using the reference standard. Sensitivity/specificity of 3D-MRCP for detecting PD were 81.2%/69.7% (p < 0.001). Sensitivity/specificity of TIRM and HASTE were 92.5%/93.9 and 98.1%/97.0%, respectively (p < 0.001 each). Grouped sensitivity/specificity of non-MRCP T2-weighted sequences were 99.8%/91.0%. Non-MRCP T2-weighted sequences were non-inferior to 3D-MRCP alone for diagnosis of PD. 20.2, 7.3%, and 2.3% of 3D-MRCP, TIRM, and HASTE, respectively, were not evaluable due to motion artifacts or insufficient duct depiction. Conclusions: Non-MRCP T2-weighted MRI sequences offer high performance for diagnosis of PD and are noninferior to 3D-MRCP alone. Trial registration: Not applicable.