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Verfasst von:Kotsougiani-Fischer, Dimitra [VerfasserIn]   i
Titel:Bone vascularized composite allotransplantation model in swine tibial defect
Titelzusatz:evaluation of surgical angiogenesis and transplant viability
Verf.angabe:Dimitra Kotsougiani MD, Caroline A. Hundepool MD, PhD, Liselotte F. Bulstra MSc, Patricia F. Friedrich AAS, Alexander Y. Shin MD, Allen T. Bishop MD
Jahr:2019
Jahr des Originals:2018
Umfang:7 S.
Teil:volume:39
 year:2019
 number:2
 pages:160-166
 extent:7
Fussnoten:First published: 05 March 2018 ; Gesehen am 05.12.2019
Titel Quelle:Enthalten in: Microsurgery
Ort Quelle:New York, NY [u.a.] : Wiley-Liss, 1979
Jahr Quelle:2019
Band/Heft Quelle:39(2019), 2, Seite 160-166
ISSN Quelle:1098-2752
Abstract:Introduction In prior small animal studies, we maintained vascularized bone allotransplant viability without long-term immunotherapy. Instead, an autogenous neoangiogenic circulation is created from implanted vessels, sufficient to maintain bone viability with only 2 weeks immunosupression. Blood flow is maintained despite rejection of the allogeneic vascular pedicle thereafter. We have previously described a large animal (swine) pre-clinical model, reconstructing tibial defects with vascularized tibial allotransplants. In this manuscript, autologous angiogenesis is evaluated in this model and correlated with bone viability. Materials and methods Allogeneic tibial segments were transplanted across a major swine leukocyte antigen mismatch. Microvascular repair of the bone VCA pedicle was combined with intraosseous implantation of an autogenous arteriovenous (AV) bundle. The bundle was ligated in group 1 (n = 4), and allowed to perfuse in group 2 (n = 4). Three-drug immunotherapy was given for 2 weeks. At 16 weeks micro-CT angiography quantified neoangiogenic vessel volume. Bone viability, rejection grade, and bone healing were analyzed. Results A substantial neoangiogenic circulation developed from the implanted AV-bundle in group 2, with vessel density superior to ligated AV-bundle controls (0.11 ± 0.05 vs. 0.01 ± 0.01, P = .029). Bone allotransplant viability was also significantly enhanced by neoangiogenesis (78.7 ± 4.4% vs. 27.7 ± 5.8%, P = .028) with higher bone healing scores (21.4 ± 2.9 vs. 12.5 ± 3.7, P = .029). Ligated control tibias demonstrated disorganized bone morphology and higher local inflammation (P = .143). Conclusion Implantation of autogenous AV bundles into vascularized bone allotransplants resulted in the rapid formation of a neoangiogenic autogenous blood supply in a swine tibia model that maintained bone viability, improved bone healing, and minimized rejection.
DOI:doi:10.1002/micr.30310
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext ; Verlag: https://doi.org/10.1002/micr.30310
 Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/micr.30310
 DOI: https://doi.org/10.1002/micr.30310
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:1677555203
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