| |  Online-Ressource |
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| Verfasst von: | Heinzelmann, Frank [VerfasserIn]  |
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| | Bethge, Wolfgang Andreas [VerfasserIn] |
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| | Beelen, Dietrich W. [VerfasserIn] |
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| | Stelljes, Matthias [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Engelhard, Marianne [VerfasserIn] |
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| | Finke, Jürgen [VerfasserIn] |
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| | Kröger, Nicolaus [VerfasserIn] |
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| | Holler, Ernst [VerfasserIn] |
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| | Bornhäuser, Martin [VerfasserIn] |
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| | Müller, Annerose [VerfasserIn] |
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| | Haubitz, Imme [VerfasserIn] |
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| | Ottinger, Hellmut [VerfasserIn] |
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| Titel: | Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma |
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| Verf.angabe: | Frank Heinzelmann, Wolfgang Bethge, Dietrich Wilhelm Beelen, Matthias Stelljes, Peter Dreger, Marianne Engelhard, Jürgen Finke, Nikolaus Kröger, Ernst Holler, Martin Bornhäuser, Annerose Müller, Imme Haubitz, Hellmut Ottinger |
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| E-Jahr: | 2018 |
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| Jahr: | June 2018 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 24.09.2019 |
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| Titel Quelle: | Enthalten in: Journal of cancer research and clinical oncology |
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| Ort Quelle: | Berlin : Springer, 1904 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 144(2018), 6, Seite 1173-1183 |
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| ISSN Quelle: | 1432-1335 |
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| Abstract: | PurposeIn patients with follicular lymphoma, secondary transformation to aggressive lymphoma (tFL) implies a poor prognosis. In principle, allogeneic haematopoietic cell transplantation (allo-HCT) offers a chance of cure for tFL but is rarely practiced. Aim of this retrospective multicenter study was to define the actual significance of allo-HCT in treatment of tFL.MethodsThe database of the German Registry for Stem Cell Transplantation (DRST) was screened for patients who underwent allo-HCT for tFL 1998-2008. Confirmation of tFL-diagnosis by local and/or pathologists of the National NHL Board was mandatory for enrolment. Gaps in reported EBMT Minimum Essential Data datasets (MED-A) were filled by local DRST data managers. Relevant HCT outcome variables were evaluated by uni- and multivariate statistical analysis.ResultsMedian age of enrolled 33 patients was 51 years with a post allo-HCT median follow-up of 7.1 years of surviving patients. At time of HCT 24/33 patients had chemosensitive disease. In 24/33 patients reduced intensity conditioning (RIC) was used. Estimated 1, 2, 5-year overall survival (OS) and event-free survival rates were 49/39/33, and 33/30/24%. Cumulative 100 days non-relapse mortality was 25%. Chemosensitive disease, RIC, and limited chronic GvHD were identified as independent prognostic factors for OS.ConclusionsAllo-HCT offers the chance of cure for tFL. |
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| DOI: | doi:10.1007/s00432-018-2633-5 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1007/s00432-018-2633-5 |
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| | DOI: https://doi.org/10.1007/s00432-018-2633-5 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Allogeneic HCT |
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| | Cure |
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| | Prognostic factors |
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| | Transformed follicular lymphoma |
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| K10plus-PPN: | 1677558741 |
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| Verknüpfungen: | → Zeitschrift |
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Allogeneic haematopoietic cell transplantation offers the chance of cure for patients with transformed follicular lymphoma / Heinzelmann, Frank [VerfasserIn]; June 2018 (Online-Ressource)
