| |  Online-Ressource |
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| Verfasst von: | Seeland, Isabel [VerfasserIn]  |
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| | Xiong, Ying [VerfasserIn] |
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| | Orlik, Christian [VerfasserIn] |
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| | Arnold, Bernd [VerfasserIn] |
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| | Samstag, Yvonne [VerfasserIn] |
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| Titel: | The actin remodeling protein cofilin is crucial for thymic αβ but not γ[delta] T-cell development |
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| Verf.angabe: | Isabel Seeland, Ying Xiong, Christian Orlik, Daniel Deibel, Sandra Prokosch, Günter Küblbeck, Beate Jahraus, Daniela De Stefano, Sonja Moos, Florian C. Kurschus, Bernd Arnold, Yvonne Samstag |
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| E-Jahr: | 2018 |
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| Jahr: | July 9, 2018 |
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| Umfang: | 21 S. |
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| Fussnoten: | Gesehen am 25.09.2019 ; Im Titel ist "delta" als griechischer Buchstabe dargestellt |
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| Titel Quelle: | Enthalten in: Public Library of SciencePLoS biology |
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| Ort Quelle: | Lawrence, KS : PLoS, 2003 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 16(2018,7) Artikel-Nummer e2005380, 21 Seiten |
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| ISSN Quelle: | 1545-7885 |
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| Abstract: | Cofilin is an essential actin remodeling protein promoting depolymerization and severing of actin filaments. To address the relevance of cofilin for the development and function of T cells in vivo, we generated knock-in mice in which T-cell-specific nonfunctional (nf) cofilin was expressed instead of wild-type (WT) cofilin. Nf cofilin mice lacked peripheral αβ T cells and showed a severe thymus atrophy. This was caused by an early developmental arrest of thymocytes at the double negative (DN) stage. Importantly, even though DN thymocytes expressed the TCRβ chain intracellularly, they completely lacked TCRβ surface expression. In contrast, nf cofilin mice possessed normal numbers of γδ T cells. Their functionality was confirmed in the γδ T-cell-driven, imiquimod (IMQ)-induced, psoriasis-like murine model. Overall, this study not only highlights the importance of cofilin for early αβ T-cell development but also shows for the first time that an actin-binding protein is differentially involved in αβ versus γδ T-cell development. |
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| DOI: | doi:10.1371/journal.pbio.2005380 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1371/journal.pbio.2005380 |
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| | Volltext: https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.2005380 |
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| | DOI: https://doi.org/10.1371/journal.pbio.2005380 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Actins |
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| | Flow cytometry |
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| | Mouse models |
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| | Phosphorylation |
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| | Small interfering RNAs |
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| | T cells |
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| | Thymocytes |
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| | Thymus |
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| K10plus-PPN: | 1677718099 |
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| Verknüpfungen: | → Zeitschrift |
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¬The¬ actin remodeling protein cofilin is crucial for thymic αβ but not γ[delta] T-cell development / Seeland, Isabel [VerfasserIn]; July 9, 2018 (Online-Ressource)
