| |  Online-Ressource |
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| Verfasst von: | Gdynia, Georg [VerfasserIn]  |
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| | Kopitz, Jürgen [VerfasserIn] |
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| | Ho, Anthony Dick [VerfasserIn] |
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| | Schirmacher, Peter [VerfasserIn] |
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| | Schmitt, Michael [VerfasserIn] |
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| | Dreger, Peter [VerfasserIn] |
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| | Sellner, Leopold [VerfasserIn] |
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| Titel: | Distinct activities of glycolytic enzymes identify chronic lymphocytic leukemia patients with a more aggressive course and resistance to chemo-immunotherapy |
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| Verf.angabe: | Georg Gdynia, Tadeusz Robak, Jürgen Kopitz, Anette Heller, Svetlana Grekova, Katarina Duglova, Gloria Laukemper, Monika Heinzel-Gutenbrunner, Cornelius Gutenbrunner, Wilfried Roth, Anthony D. Ho, Peter Schirmacher, Michael Schmitt, Peter Dreger, Leopold Sellner |
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| E-Jahr: | 2018 |
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| Jahr: | 5 June 2018 |
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| Umfang: | 9 S. |
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| Fussnoten: | Gesehen am 25.09.2019 |
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| Titel Quelle: | Enthalten in: EBioMedicine |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier, 2014 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 32(2018), Seite 125-133 |
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| ISSN Quelle: | 2352-3964 |
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| Abstract: | A higher capacity to grow under hypoxic conditions can lead to a more aggressive behavior of tumor cells. Determining tumor activity under hypoxia may identify chronic lymphocytic leukemia (CLL) with aggressive clinical course and predict response to chemo-immunotherapy (CIT). A metabolic score was generated by determining pyruvate kinase and lactate dehydrogenase, key enzymes of glycolysis, ex vivo in primary CLL samples under normoxic and hypoxic conditions. This score was further correlated with clinical endpoints and response to CIT in 96 CLL patients. 45 patients were classified as metabolic high risk (HR), 51 as low risk (LR). Treatment-free survival (TFS) was significantly shorter in HR patients (median 394 vs 723days, p=.021). 15 HR patients and 14 LR patients received CIT after sample acquisition. HR patients had a significantly shorter progression-free survival after treatment compared to LR patients (median 216days vs not reached, p=.008). Multivariate analysis evaluating age, IGHV, TP53 deletion or mutation and 11q22-23 deletion besides the capacity of tumor cells to grow under severe hypoxic conditions identified the metabolic profile as the strongest independent risk factor for shorter TFS (hazard ratio 2.37, p=.011). The metabolic risk can provide prognostic and predictive information complementary to genetic biomarkers and identify patients who might benefit from alternative treatment approaches. |
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| DOI: | doi:10.1016/j.ebiom.2018.05.030 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.ebiom.2018.05.030 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S2352396418301956 |
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| | DOI: https://doi.org/10.1016/j.ebiom.2018.05.030 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | CLL |
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| | High-risk |
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| | LDH |
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| | Metabolism |
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| | PK M2 |
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| K10plus-PPN: | 1677726148 |
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| Verknüpfungen: | → Zeitschrift |
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Distinct activities of glycolytic enzymes identify chronic lymphocytic leukemia patients with a more aggressive course and resistance to chemo-immunotherapy / Gdynia, Georg [VerfasserIn]; 5 June 2018 (Online-Ressource)
