Status: Bibliographieeintrag
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| Verfasst von: | Schoch, Arne [VerfasserIn]  |
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| | Pahle, Jürgen [VerfasserIn] |
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| Titel: | Requirements for band-pass activation of Ca2+-sensitive proteins such as NFAT |
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| Verf.angabe: | Arne Schoch, Jürgen Pahle |
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| Jahr: | 2019 |
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| Jahr des Originals: | 2018 |
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| Umfang: | 12 S. |
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| Fussnoten: | Available online 29 October 2018 ; Gesehen am 01.10.2019 ; Im Text ist "2+" hochgestellt |
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| Titel Quelle: | Enthalten in: Biophysical chemistry |
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| Ort Quelle: | Amsterdam [u.a.] : Elsevier Science, 1973 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 245(2019), Seite 41-52 |
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| ISSN Quelle: | 1873-4200 |
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| Abstract: | Several proteins are sensitive to frequency-modulated oscillations of calcium levels. Most of them exhibit increased activities for faster frequencies, a characteristic here referred to as high-pass activation. In contrast, the transcription factor NFAT is optimally activated at a specific frequency, a behaviour we call band-pass activation. We constructed a kinetic model of NFAT activation, confirming its ability for band-pass activation at experimentally observed frequencies. To characterise the requirements for band-pass activation further, we developed a minimal model, identifying antagonistic, calcium-dependent regulation with differently responsive regulators as essential for band-pass activation. Further, in optimisations cooperative binding proved to be an important feature for distinct frequency-decoding in models of high- and band-pass activation. A subsequent analysis of the optimised parameter sets revealed the most sensitive parameters along with additional preconditions for efficient decoding. Our analysis is not limited to NFAT, but potentially applies to any protein showing high- or band-pass activation. |
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| DOI: | doi:10.1016/j.bpc.2018.10.005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.bpc.2018.10.005 |
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| | Verlag: http://www.sciencedirect.com/science/article/pii/S0301462218302618 |
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| | DOI: https://doi.org/10.1016/j.bpc.2018.10.005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Calcium Signalling |
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| | Cooperativity |
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| | Decoding |
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| | Frequency |
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| | Nuclear factor of activated T cells |
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| | Oscillation |
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| K10plus-PPN: | 1677987693 |
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| Verknüpfungen: | → Zeitschrift |
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Requirements for band-pass activation of Ca2+-sensitive proteins such as NFAT / Schoch, Arne [VerfasserIn]; 2019 (Online-Ressource)
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