Navigation überspringen
Universitätsbibliothek Heidelberg
Status: Bibliographieeintrag

Verfügbarkeit
Standort: ---
Exemplare: ---
heiBIB
 Online-Ressource
Verfasst von:Sharopov, Farukh [VerfasserIn]   i
 Valiev, Abdujabbor [VerfasserIn]   i
 Gulmurodov, Isomiddin [VerfasserIn]   i
 Sobeh, Mansour [VerfasserIn]   i
 Satyal, Prabodh [VerfasserIn]   i
 Wink, Michael [VerfasserIn]   i
Titel:Alkaloid content, antioxidant and cytotoxic activities of various parts of papaver somniferum
Verf.angabe:Farukh Sharopov, Abdujabbor Valiev, Isomiddin Gulmurodov, Mansour Sobeh, Prabodh Satyal, and Michael Wink
E-Jahr:2018
Jahr:03 September 2018
Umfang:6 S.
Fussnoten:Gesehen am 01.10.2019
Titel Quelle:Enthalten in: Pharmaceutical chemistry journal
Ort Quelle:Dordrecht [u.a.] : Springer Science + Business Media B.V, 1967
Jahr Quelle:2018
Band/Heft Quelle:52(2018), 5, Seite 459-463
ISSN Quelle:1573-9031
Abstract:Poppy (Papaver somniferum) is a traditional source of isoquinoline alkaloids, especially morphine, codeine and papaverine that exhibit a wide spectrum of therapeutic effects. Due to beneficial properties, poppy has been used by humankind for several thousand years and is still being used around the world. The present study was aimed to investigate alkaloid composition and biological activity of various parts of the plant (leaves, stems, roots, capsules, flowers, seeds) in an ornamental variety of P. somniferum. The alkaloid content rangedwithin 0.16 - 6.5 mg/g fresh weight of raw plant material. The major components of the alkaloid fraction were papaverine (37.7 - 2062.9 μg/g), codeine (7.4 - 1280.5 μg/g) and morphine (3.25 - 929.3 μg/g). The P. somniferum alkaloid extract produced a strong antioxidant effect, which was evaluated using the radical-scavenging DPPH, ABTS and FRAP assays. The antioxidant properties were characterized by IC50 values ranging within 35.1 - 157.6 μg/mL for DPPH radical and 138.5 - 306.3 μg/mL for ABTS∙•+ radical scavenging. The ferric reducing antioxidant power (FRAP) values varied from 59.75 to 1348.71 mM FeSO4/g extract. The alkaloid extract was active against all human tumor cell lines studied (HeLa, Caco-2, MCF-7, CCRF-CEM and CEM/ADR 5000). The methanol extract exhibited a pronounced cytotoxicity against most of cancer cell lines studied, especially those with a low expression of ABC transporters.
DOI:doi:10.1007/s11094-018-1839-9
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1007/s11094-018-1839-9
 DOI: https://doi.org/10.1007/s11094-018-1839-9
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:antioxidant
 cytotoxicity
 morphine
 Papaver somniferum; extract; alkaloids
K10plus-PPN:1677987987
Verknüpfungen:→ Zeitschrift

Permanenter Link auf diesen Titel (bookmarkfähig):  https://katalog.ub.uni-heidelberg.de/titel/68434582   QR-Code
zum Seitenanfang