Status: Bibliographieeintrag
Standort: ---
Exemplare:
---
| |  Online-Ressource |
|---|
| Verfasst von: | Sousa-Pereira, Patrícia de [VerfasserIn]  |
|---|
| | Pierini, Virginia [VerfasserIn] |
|---|
| | Fackler, Oliver Till [VerfasserIn] |
|---|
| Titel: | The antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists |
|---|
| Verf.angabe: | Patrícia de Sousa-Pereira, Joana Abrantes, Stefan Bauernfried, Virginia Pierini, Pedro José Esteves, Oliver T. Keppler, Massimo Pizzato, Veit Hornung, Oliver T. Fackler, Hanna-Mari Baldauf |
|---|
| Jahr: | 2019 |
|---|
| Jahr des Originals: | 2018 |
|---|
| Umfang: | 11 S. |
|---|
| Fussnoten: | First published: 19 December 2018 ; Gesehen am 19.11.2019 |
|---|
| Titel Quelle: | Enthalten in: Journal of general virology |
|---|
| Ort Quelle: | Reading : Soc., 1967 |
|---|
| Jahr Quelle: | 2019 |
|---|
| Band/Heft Quelle: | 100(2019), 2, Seite 278-288 |
|---|
| ISSN Quelle: | 1465-2099 |
|---|
| Abstract: | A first step towards the development of a human immunodeficiency virus (HIV) animal model has been the identification and surmounting of species-specific barriers encountered by HIV along its replication cycle in cells from small animals. Serine incorporator proteins 3 (SERINC3) and 5 (SERINC5) were recently identified as restriction factors that reduce HIV-1 infectivity. Here, we compared the antiviral activity of SERINC3 and SERINC5 among mice, rats and rabbits, and their susceptibility to viral counteraction to their human counterparts. In the absence of viral antagonists, rodent and lagomorph SERINC3 and SERINC5 displayed anti-HIV activity in a similar range to human controls. Vesicular stomatitis virus G protein (VSV-G) pseudotyped virions were considerably less sensitive to restriction by all SERINC3/5 orthologs. Interestingly, HIV-1 Nef, murine leukemia virus (MLV) GlycoGag and equine infectious anemia virus (EIAV) S2 counteracted the antiviral activity of all SERINC3/5 orthologs with similar efficiency. Our results demonstrate that the antiviral activity of SERINC3/5 proteins is conserved in rodents and rabbits, and can be overcome by all three previously reported viral antagonists., |
|---|
| DOI: | doi:10.1099/jgv.0.001201 |
|---|
| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1099/jgv.0.001201 |
|---|
| | Verlag: https://www.microbiologyresearch.org/content/journal/jgv/10.1099/jgv.0.001201 |
|---|
| | DOI: https://doi.org/10.1099/jgv.0.001201 |
|---|
| Datenträger: | Online-Ressource |
|---|
| Sprache: | eng |
|---|
| K10plus-PPN: | 1678026999 |
|---|
| Verknüpfungen: | → Zeitschrift |
|---|
¬The¬ antiviral activity of rodent and lagomorph SERINC3 and SERINC5 is counteracted by known viral antagonists / Sousa-Pereira, Patrícia de [VerfasserIn]; 2019 (Online-Ressource)
68434875
