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Verfasst von:Bendinger, Alina L. [VerfasserIn]   i
 Debus, Charlotte [VerfasserIn]   i
 Glowa, Christin [VerfasserIn]   i
 Storath, Martin [VerfasserIn]   i
 Karger, Christian [VerfasserIn]   i
Titel:Bolus arrival time estimation in dynamic contrast-enhanced magnetic resonance imaging of small animals based on spline models
Verf.angabe:Alina L. Bendinger, Charlotte Debus, Christin Glowa, Christian P. Karger, Jörg Peter and Martin Storath
E-Jahr:2019
Jahr:5 February 2019
Umfang:12 S.
Fussnoten:Gesehen am 31.10.2019
Titel Quelle:Enthalten in: Physics in medicine and biology
Ort Quelle:Bristol : IOP Publ., 1956
Jahr Quelle:2019
Band/Heft Quelle:64(2019,4) Artikel-Nummer 045003, 12 Seiten
ISSN Quelle:1361-6560
Abstract:Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) is used to quantify perfusion and vascular permeability. In most cases a bolus arrival time (BAT) delay exists between the arterial input function (AIF) and the contrast agent arrival in the tissue of interest which needs to be estimated. Existing methods for BAT estimation are tailored to tissue concentration curves, which have a fast upslope to the peak as frequently observed in patient data. However, they may give poor results for curves that do not have this characteristic shape such as tissue concentration curves of small animals. In this paper, we propose a method for BAT estimation of signals that do not have a fast upslope to their peak. The model is based on splines which are able to adapt to a large variety of concentration curves. Furthermore, the method estimates BATs on a continuous time scale. All relevant model parameters are automatically determined by generalized cross validation. We use simulated concentration curves of small animal and patient settings to assess the accuracy and robustness of our approach. The proposed method outperforms a state-of-the-art method for small animal data and it gives competitive results for patient data. Finally, it is tested on in vivo acquired rat data where accuracy of BAT estimation was also improved upon the state-of-the-art method. The results indicate that the proposed method is suitable for accurate BAT estimation of DCE-MRI data, especially for small animals.
DOI:doi:10.1088/1361-6560/aafce7
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1088/1361-6560/aafce7
 Verlag: https://iopscience.iop.org/article/10.1088/1361-6560/aafce7
 DOI: https://doi.org/10.1088/1361-6560/aafce7
Datenträger:Online-Ressource
Sprache:eng
K10plus-PPN:167802970X
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