Peridural analgesia does not impact survival in patients after colon cancer resection

• Verfasst von: Wurster, Elena Felicia [VerfasserIn]
• Verfasst von: Pianka, Frank [VerfasserIn]
• Verfasst von: Warschkow, René [VerfasserIn]
• Verfasst von: Antony, Pia-Anita [VerfasserIn]
• Verfasst von: Brenner, Thorsten [VerfasserIn]
• Verfasst von: Weigand, Markus A. [VerfasserIn]
• Verfasst von: Schmied, Bruno [VerfasserIn]
• Verfasst von: Büchler, Markus W. [VerfasserIn]
• Verfasst von: Tarantino, Ignazio [VerfasserIn]
• Verfasst von: Ulrich, Alexis [VerfasserIn]
• Titel: Peridural analgesia does not impact survival in patients after colon cancer resection
• Titelzusatz: a retrospective propensity score-adjusted analysis
• Verf.angabe: Elena F. Wurster, Frank Pianka, Rene Warschkow, Pia Antony, Thorsten Brenner, Markus A. Weigand, Bruno M. Schmied, Markus W. Büchler, Ignazio Tarantino, Alexis Ulrich
• E-Jahr: 2019
• Jahr: 6 June 2019
• Umfang: 11 S.
• Fussnoten: Published online: 6 June 2019 ; Gesehen am 02.10.2019
• Titel Quelle: Enthalten in: International journal of colorectal disease
• Ort Quelle: Berlin : Springer, 1986
• Jahr Quelle: 2019
• Band/Heft Quelle: 34(2019), 7, Seite 1283-1293
• ISSN Quelle: 1432-1262
• DOI: doi:10.1007/s00384-019-03315-0
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Cancer-specific survival
• Sach-SW: Colon cancer
• Sach-SW: Overall survival
• Sach-SW: Peridural analgesia
• K10plus-PPN: 1678053503

Abstract

PurposeTo assess the putative impact of peridural analgesia on oncological outcome in patients undergoing resection of stages I-IV colon cancer.MethodsIn a single-center study, 876 patients undergoing resection for primary colon cancer (AJCC stages I-IV) between 2001 and 2014 were analyzed. Mean follow-up of the entire cohort was 4.2 ± 3.5 years. Patients who did and did not receive peridural analgesia were compared using Cox regression and propensity score analyses.ResultsOverall, 208 patients (23.7%) received peridural analgesia. Patients’ characteristics were biased with regard to the use of peridural analgesia (propensity score 0.296 ± 0.129 vs. 0.219 ± 0.108, p < 0.001). After propensity score matching, the use of peridural analgesia had no impact on overall (HR 0.81, 95% CI 0.59-1.11, p = 0.175), cancer-specific (HR 0.72, 95% CI 0.48-1.09, p = 0.111), and disease-free survival (HR 0.89, 95% CI 0.66-1.19, p = 0.430). The 5-year overall survival after propensity score matching was 60.9% (95% CI 54.8-67.7%) for patients treated with peridural analgesia compared with 54.1% (95% CI 49.5-59.1%) for patients not treated with peridural analgesia. Cancer-specific and disease-free survival showed similar non-significant results.ConclusionsPeridural analgesia in patients after colon cancer resection was not associated with a better oncological outcome after risk adjusting in multivariable Cox regression and propensity score analyses. Hence, oncological outcome should not serve as a reason for the use of peridural analgesia in patients with colon cancer.