| |  Online-Ressource |
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| Verfasst von: | Vries, Paul S. de [VerfasserIn]  |
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| | Brown, Michael R. [VerfasserIn] |
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| | Bentley, Amy R. [VerfasserIn] |
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| | Sung, Yun J. [VerfasserIn] |
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| | Winkler, Thomas W. [VerfasserIn] |
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| | Ntalla, Ioanna [VerfasserIn] |
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| | Schwander, Karen [VerfasserIn] |
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| | Kraja, Aldi T. [VerfasserIn] |
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| | Guo, Xiuqing [VerfasserIn] |
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| | Franceschini, Nora [VerfasserIn] |
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| | Cheng, Ching-Yu [VerfasserIn] |
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| | Sim, Xueling [VerfasserIn] |
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| | Vojinovic, Dina [VerfasserIn] |
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| | Huffman, Jennifer E. [VerfasserIn] |
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| | Musani, Solomon K. [VerfasserIn] |
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| | Li, Changwei [VerfasserIn] |
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| | Feitosa, Mary F. [VerfasserIn] |
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| | Richard, Melissa A. [VerfasserIn] |
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| | Noordam, Raymond [VerfasserIn] |
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| | Aschard, Hugues [VerfasserIn] |
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| | Jonas, Jost B. [VerfasserIn] |
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| Titel: | Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions |
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| Verf.angabe: | Paul S. de Vries, Michael R. Brown, Amy R. Bentley, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Karen Schwander, Aldi T. Kraja, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jennifer E. Huffman, Solomon K. Musani, Changwei Li, Mary F. Feitosa, Melissa A. Richard, Raymond Noordam, Hugues Aschard et al. |
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| E-Jahr: | 2019 |
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| Jahr: | January 29, 2019 |
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| Umfang: | 22 S. |
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| Fussnoten: | Gesehen am 04.10.2019 |
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| Titel Quelle: | Enthalten in: American journal of epidemiology |
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| Ort Quelle: | Oxford : Oxford Univ. Press, 1921 |
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| Jahr Quelle: | 2019 |
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| Band/Heft Quelle: | 188(2019), 6, Seite 1033-1054 |
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| ISSN Quelle: | 1476-6256 |
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| Abstract: | A person's lipid profile is influenced by genetic variants and alcohol consumption, but the contribution of interactions between these exposures has not been studied. We therefore incorporated gene-alcohol interactions into a multiancestry genome-wide association study of levels of high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides. We included 45 studies in stage 1 (genome-wide discovery) and 66 studies in stage 2 (focused follow-up), for a total of 394,584 individuals from 5 ancestry groups. Analyses covered the period July 2014-November 2017. Genetic main effects and interaction effects were jointly assessed by means of a 2-degrees-of-freedom (df) test, and a 1-df test was used to assess the interaction effects alone. Variants at 495 loci were at least suggestively associated (P < 1 x 10(-6)) with lipid levels in stage 1 and were evaluated in stage 2, followed by combined analyses of stage 1 and stage 2. In the combined analysis of stages 1 and 2, a total of 147 independent loci were associated with lipid levels at P < 5 x 10(-8) using 2-df tests, of which 18 were novel. No genome-wide-significant associations were found testing the interaction effect alone. The novel loci included several genes (proprotein convertase subtilisin/kexin type 5 (PCSK5), vascular endothelial growth factor B (VEGFB), and apolipoprotein B mRNA editing enzyme, catalytic polypeptide 1 (APOBEC1) complementation factor (A1CF)) that have a putative role in lipid metabolism on the basis of existing evidence from cellular and experimental models. |
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| DOI: | doi:10.1093/aje/kwz005 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1093/aje/kwz005 |
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| | Volltext: https://academic.oup.com/aje/article/188/6/1033/5304469 |
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| | DOI: https://doi.org/10.1093/aje/kwz005 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | alcohol consumption |
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| | blood-lipids |
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| | cholesterol |
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| | consumption |
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| | coronary-heart-disease |
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| | density-lipoprotein cholesterol |
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| | gene-environment interactions |
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| | gene-lifestyle interactions |
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| | genome-wide association studies |
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| | hdl cholesterol |
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| | individuals |
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| | lipids |
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| | low-frequency |
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| | metaanalysis |
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| | plasma |
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| | triglycerides |
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| | vegf-b |
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| K10plus-PPN: | 1678136336 |
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| Verknüpfungen: | → Zeitschrift |
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Multiancestry genome-wide association study of lipid levels incorporating gene-alcohol interactions / Vries, Paul S. de [VerfasserIn]; January 29, 2019 (Online-Ressource)
