Similarity and strength of glomerular odor representations define a neural metric of sniff-invariant discrimination time

• Verfasst von: Bhattacharjee, Anindya S. [VerfasserIn]
• Verfasst von: Kuner, Thomas [VerfasserIn]
• Titel: Similarity and strength of glomerular odor representations define a neural metric of sniff-invariant discrimination time
• Verf.angabe: Anindya S. Bhattacharjee, Sasank Konakamchi, Dmitrij Turaev, Roberto Vincis, Daniel Nunes, Atharva A. Dingankar, Hartwig Spors, Alan Carleton, Thomas Kuner, and Nixon M. Abraham
• E-Jahr: 2019
• Jahr: 10 September 2019
• Umfang: 19 S.
• Fussnoten: Gesehen am 07.10.2019
• Titel Quelle: Enthalten in: Cell reports
• Ort Quelle: Maryland Heights, MO : Cell Press, 2012
• Jahr Quelle: 2019
• Band/Heft Quelle: 28(2019), 11, Seite 2966-2978.e5
• ISSN Quelle: 2211-1247
• DOI: doi:10.1016/j.celrep.2019.08.015
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Euclidean distance
• Sach-SW: intrinsic optical signal imaging
• Sach-SW: odor discrimination time
• Sach-SW: olfactory bulb
• Sach-SW: sniffing
• K10plus-PPN: 167819168X

Abstract

Summary - The olfactory environment is first represented by glomerular activity patterns in the olfactory bulb. It remains unclear how these representations intersect with sampling behavior to account for the time required to discriminate odors. Using different chemical classes, we investigate glomerular representations and sniffing behavior during olfactory decision-making. Mice rapidly discriminate odorants and learn to increase sniffing frequency at a fixed latency after trial initiation, independent of odor identity. Relative to the increase in sniffing frequency, monomolecular odorants are discriminated within 10-40 ms, while binary mixtures require an additional 60-70 ms. Intrinsic imaging of glomerular activity in anesthetized and awake mice reveals that Euclidean distance between activity patterns and the time needed for discriminations are anti-correlated. Therefore, the similarity of glomerular patterns and their activation strengths, rather than sampling behavior, define the extent of neuronal processing required for odor discrimination, establishing a neural metric to predict olfactory discrimination time.