| |  Online-Ressource |
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| Verfasst von: | Fastner, Christian [VerfasserIn]  |
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| | Behnes, Michael [VerfasserIn] |
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| | Sartorius, Benjamin [VerfasserIn] |
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| | Wenke, Annika [VerfasserIn] |
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| | Lang, Siegfried [VerfasserIn] |
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| | Yücel, Gökhan [VerfasserIn] |
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| | Sattler, Katherine [VerfasserIn] |
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| | Rusnak, Jonas [VerfasserIn] |
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| | Saleh, Ahmad [VerfasserIn] |
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| | Barth, Christian [VerfasserIn] |
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| | Hoffmann, Ursula [VerfasserIn] |
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| | Borggrefe, Martin [VerfasserIn] |
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| | Akın, Ibrahim [VerfasserIn] |
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| Titel: | Interventional left atrial appendage closure affects the metabolism of acylcarnitines |
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| Verf.angabe: | Christian Fastner, Michael Behnes, Benjamin Sartorius, Annika Wenke, Siegfried Lang, Gökhan Yücel, Katherine Sattler, Jonas Rusnak, Ahmad Saleh, Christian Barth, Kambis Mashayekhi, Ursula Hoffmann, Martin Borggrefe and Ibrahim Akin |
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| E-Jahr: | 2018 |
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| Jahr: | 7 February 2018 |
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| Umfang: | 12 S. |
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| Fussnoten: | Gesehen am 07.10.2019 |
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| Titel Quelle: | Enthalten in: International journal of molecular sciences |
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| Ort Quelle: | Basel : Molecular Diversity Preservation International, 2000 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 19(2018,2) Artikel-Nummer 500, 12 Seiten |
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| ISSN Quelle: | 1422-0067 |
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| | 1661-6596 |
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| Abstract: | Background: Left atrial appendage closure (LAAC) represents the interventional alternative to oral anticoagulation for stroke prevention in atrial fibrillation (AF). The metabolism of acylcarnitines was shown to affect cardiovascular diseases. This study evaluates the influence of successful LAAC on the metabolism of acylcarnitines. Methods: Patients undergoing successful LAAC were enrolled prospectively. Peripheral blood samples for metabolomics measurements were collected immediately before (i.e., index) and six months after LAAC (i.e., mid-term). A targeted metabolomics analysis based on electrospray ionization-liquid chromatography-mass spectrometry (ESI-LC-MS/MS) and MS/MS measurements was performed. Results: 44 patients with non-valvular AF (median CHA2DS2-VASc score 4, median HAS-BLED score 4) and successful LAAC were included. Significant changes in acylcarnitine levels were found in the total cohort, which were mainly attributed to patients with impaired left ventricular and renal function, elevated amino-terminal pro-brain natriuretic peptide (NT-proBNP) and diabetes mellitus. Adjusted multivariable regression models revealed significant changes of five metabolites over mid-term follow-up: C2, C14:1, C16, and C18:1 decreased significantly (each p < 0.05); short-chain C5 acylcarnitine plasma levels increased significantly (p < 0.05). Conclusion: This study demonstrates that successful LAAC affects the metabolism of acylcarnitines at mid-term follow-up. |
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| DOI: | doi:10.3390/ijms19020500 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
kostenfrei: Volltext: https://doi.org/10.3390/ijms19020500 |
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| | kostenfrei: Volltext: https://www.mdpi.com/1422-0067/19/2/500 |
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| | DOI: https://doi.org/10.3390/ijms19020500 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | acylcarnitines |
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| | atrial fibrillation |
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| | left atrial appendage |
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| | left atrial appendage closure |
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| | metabolomics |
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| K10plus-PPN: | 1678197653 |
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| Verknüpfungen: | → Zeitschrift |
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Interventional left atrial appendage closure affects the metabolism of acylcarnitines / Fastner, Christian [VerfasserIn]; 7 February 2018 (Online-Ressource)
