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Status: Bibliographieeintrag

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Verfasst von:Michel, Laura L. [VerfasserIn]   i
 Sommer, Laura [VerfasserIn]   i
 González Silos, Rosa [VerfasserIn]   i
 Lorenzo Bermejo, Justo [VerfasserIn]   i
 Au, Alexandra von [VerfasserIn]   i
 Seitz, Julia [VerfasserIn]   i
 Hennigs, André [VerfasserIn]   i
 Smetanay, Katharina [VerfasserIn]   i
 Golatta, Michael [VerfasserIn]   i
 Heil, Jörg [VerfasserIn]   i
 Schütz, Florian [VerfasserIn]   i
 Sohn, Christof [VerfasserIn]   i
 Schneeweiss, Andreas [VerfasserIn]   i
 Marmé, Frederik [VerfasserIn]   i
Titel:Prediction of local recurrence risk after neoadjuvant chemotherapy in patients with primary breast cancer
Titelzusatz:clinical utility of the MD Anderson Prognostic Index
Verf.angabe:Laura L. Michel, Laura Sommer, Rosa González Silos, Justo Lorenzo Bermejo, Alexandra von Au, Julia Seitz, André Hennigs, Katharina Smetanay, Michael Golatta, Jörg Heil, Florian Schütz, Christof Sohn, Andreas Schneeweiss, Frederik Marmé
E-Jahr:2019
Jahr:January 31, 2019
Umfang:11 S.
Fussnoten:Gesehen am 24.10.2019
Titel Quelle:Enthalten in: PLOS ONE
Ort Quelle:San Francisco, California, US : PLOS, 2006
Jahr Quelle:2019
Band/Heft Quelle:14(2019,1) Artikel-Nummer e0211337, 11 Seiten
ISSN Quelle:1932-6203
Abstract:Background Locoregional recurrence after neoadjuvant chemotherapy for primary breast cancer is associated with poor prognosis. It is essential to identify patients at high risk of locoregional recurrence who may benefit from extended local therapy. Here, we examined the prediction accuracy and clinical applicability of the MD Anderson Prognostic Index (MDAPI). Methods Prospective clinical data from 456 patients treated between 2003 and 2011 was analyzed. The Kaplan-Meier method was used to examine the probabilities of locoregional recurrence, local recurrence and distant metastases according to individual prognosis score, stratified by type of surgery (breast conserving therapy or mastectomy). The possible confounding of the relationship between recurrence risk and MDAPI by established risk factors was accounted for in multiple survival regression models. To define the clinical utility of the MDAPI we analyzed its performance to predict locoregional recurrence censoring patients with prior or simultaneous distant metastases. Results Mastectomized patients (42% of the patients) presented with more advanced tumor stage, lower tumor grade, hormone-receptor positive disease and consequently lower pathological complete response rates. Only a few patients presented with high-risk scores (2,7% MDAPI≥3). All patients with high-risk MDAPI score (MDAPI ≥3) who developed locoregional recurrence were simultaneously affected by distant metastases. Conclusion Our data do not support a clinical utility of the MDAPI to guide local therapy.
DOI:doi:10.1371/journal.pone.0211337
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1371/journal.pone.0211337
 Verlag: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0211337
 DOI: https://doi.org/10.1371/journal.pone.0211337
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Breast cancer
 Cancer chemotherapy
 Cancer treatment
 Lymph nodes
 Mastectomy
 Radiation therapy
 Surgical and invasive medical procedures
 Surgical oncology
K10plus-PPN:1678394181
Verknüpfungen:→ Zeitschrift

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