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Verfasst von:Kubera, Katharina Maria [VerfasserIn]   i
 Hirjak, Dusan [VerfasserIn]   i
 Barth, Anja [VerfasserIn]   i
 Wolf, Nadine D. [VerfasserIn]   i
 Wolf, Robert Christian [VerfasserIn]   i
Titel:Cortical folding abnormalities in patients with schizophrenia who have persistent auditory verbal hallucinations
Verf.angabe:Katharina M. Kubera, Philipp A. Thomann, Dusan Hirjak, Anja Barth, Fabio Sambataro, Nenad Vasic, Nadine D. Wolf, Karel Frasch, R. Christian Wolf
E-Jahr:2018
Jahr:February 2018
Umfang:10 S.
Fussnoten:Gesehen am 10.10.2019
Titel Quelle:Enthalten in: European neuropsychopharmacology
Ort Quelle:Amsterdam : Elsevier, 1990
Jahr Quelle:2018
Band/Heft Quelle:28(2018), 2, Seite 297-306
ISSN Quelle:1873-7862
Abstract:In schizophrenia temporal cortical volume loss differs between patients presenting with persistent auditory verbal hallucinations (pAVH) in contrast to those without hallucinatory symptoms (nAVH). However, it is unknown whether this deficit reflects a neural signature of neurodevelopmental origin or if abnormal temporal cortical volume is reflective of factors which may be relevant at later stages of the disorder. Here, we tested the hypothesis that local gyrification index (LGI) in regions of the temporal cortex differs between patients with pAVH (n=10) and healthy controls (n=14), and that abnormal temporal LGI discriminates between pAVH and nAVH (n=10). Structural magnetic resonance imaging at 3T along with surface-based data analysis methods was used. Contrary to our expectations, patients with pAVH showed lower LGI in Broca´s region compared to both healthy persons and nAVH. Compared to nAVH, those individuals presenting with pAVH also showed lower LGI in right Broca's homologue and right superior middle frontal cortex, together with increased LGI in the precuneus and superior parietal cortex. Regions with abnormal LGI common to both patient samples were found in anterior cingulate and superior frontal areas. Inferior cortical regions exhibiting abnormal LGI in pAVH patients were associated with overall symptom load (BPRS), but not with measures of AVH symptom severity. The pattern of abnormal cortical folding in this sample suggests a neurodevelopmental signature in Broca's region, consistent with current AVH models emphasizing the pivotal role of language circuits and inner speech. Temporal cortical deficits may characterize patients with pAVH during later stages of the disorder.
DOI:doi:10.1016/j.euroneuro.2017.12.009
URL:Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.

Volltext: https://doi.org/10.1016/j.euroneuro.2017.12.009
 Volltext: http://www.sciencedirect.com/science/article/pii/S0924977X17320357
 DOI: https://doi.org/10.1016/j.euroneuro.2017.12.009
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Schizophrenia
 Auditory verbal hallucinations
 Broca's region
 Local gyrification index
 Magnetic resonance imaging
K10plus-PPN:1678652474
Verknüpfungen:→ Zeitschrift

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