Reference ranges and determinants of tricuspid regurgitation velocity in healthy adults assessed by two-dimensional Doppler-echocardiography

• Verfasst von: Marra, Alberto M. [VerfasserIn]
• Verfasst von: Eichstaedt, Christina [VerfasserIn]
• Verfasst von: Benjamin, Nicola [VerfasserIn]
• Verfasst von: Grünig, Ekkehard [VerfasserIn]
• Titel: Reference ranges and determinants of tricuspid regurgitation velocity in healthy adults assessed by two-dimensional Doppler-echocardiography
• Verf.angabe: Alberto M. Marra, Robert Naeije, Francesco Ferrara, Olga Vriz, Anna Agnese Stanziola, Michele D’Alto, Antonello D’Andrea, Luca Carannante, Christina Alessandra Eichstaedt, Antonio Cittadini, Nicola Benjamin, Ekkehard Grünig, Eduardo Bossone
• E-Jahr: 2018
• Jahr: November 2018
• Umfang: 9 S.
• Fussnoten: Gesehen am 14.10.2019
• Titel Quelle: Enthalten in: Respiration
• Ort Quelle: Basel : Karger, 1944
• Jahr Quelle: 2018
• Band/Heft Quelle: 96(2018), 5, Seite 425-433
• ISSN Quelle: 1423-0356
• DOI: doi:10.1159/000490191
• Datenträger: Online-Ressource
• Sprache: eng
• K10plus-PPN: 1678799459

Abstract

Background: Tricuspid regurgitation velocity (TRV) is the most widely used parameter by transthoracic echocardiography (TTE) in the evaluation of patients with suspected pulmonary hypertension (PH). Objectives: To explore the physiologic range of TRV in healthy adults and to investigate its clinical determinants. Methods: In the first part of the study, 614 healthy individuals (age 45.7± 14.7 years, 60.26% women) were prospectively assessed by TTE. In the second part, a pooled meta-analysis of 16 already published studies with TRV values in healthy subjects (<i>n</i> = 981) was performed. Statistical analysis included the calculation of 95% quantiles for defining reference ranges. Results: In the prospectively enrolled cohort, mean TRV was 2.01 ± 0.29 m/s (5-95% CI 1.987-2.033 m/s). It was significantly but weakly positively correlated with age, body mass index, systolic blood pressure, diastolic blood pressure, left atrial volume and negative with mitral inflow E/A ratio. No significant differences were found between males and females. The prospectively enrolled data revealed similar values to the literature-based datasets resulting in a mean TRV of 1.96 m/s (95% CI 1.91-2.02 m/s) and a 95% quantile of 2.55 m/s.Conclusions: To the best of our knowledge, this is the largest dataset to describe reference ranges of TRV and their clinical determinants in healthy adults years. The determined cut-off value of 2.55 m/s of this study has to be confirmed in specific pathologies such as patients at risk of PH.