| |  Online-Ressource |
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| Verfasst von: | Peters, Leila [VerfasserIn]  |
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| | Blank, Susanne [VerfasserIn] |
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| | Nienhüser, Henrik [VerfasserIn] |
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| | Dorr, Sara [VerfasserIn] |
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| | Haag, Georg Martin [VerfasserIn] |
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| | Jäger, Dirk [VerfasserIn] |
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| | Bruckner, Thomas [VerfasserIn] |
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| | Müller, Beat P. [VerfasserIn] |
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| | Ott, Katja [VerfasserIn] |
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| | Büchler, Markus W. [VerfasserIn] |
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| | Ulrich, Alexis [VerfasserIn] |
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| | Schmidt, Thomas [VerfasserIn] |
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| Titel: | Prognostic differences in 8th edition TNM staging of esophagogastric adenocarcinoma after neoadjuvant treatment |
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| Verf.angabe: | Leila Sisic, Susanne Blank, Henrik Nienhüser, Sara Dorr, Georg Martin Haag, Dirk Jäger, Thomas Bruckner, Beat P. Müller-Stich, Katja Ott, Markus W. Büchler, Alexis Ulrich, Thomas Schmidt |
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| E-Jahr: | 2018 |
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| Jahr: | 7 July 2018 |
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| Umfang: | 11 S. |
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| Fussnoten: | Gesehen am 14.10.2019 |
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| Titel Quelle: | Enthalten in: European journal of surgical oncology |
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| Ort Quelle: | Burlington, Mass. : Harcourt, 1995 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 44(2018), 10, Seite 1646-1656 |
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| ISSN Quelle: | 1532-2157 |
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| Abstract: | Background - Prognostic differences between pTN- and ypTN-categories and the prognostic accuracy of the 8th edition UICC-pTNM- and AJCC-ypTNM-staging-system for esophageal and gastric adenocarcinoma are unclear. - Methods - We retrospectively analyzed data of 740 patients with esophagogastric adenocarcinoma, who underwent curative surgery (344 after neoadjuvant treatment [NT]) at our institution. Survival analyses were performed according to Kaplan-Meier (log-rank test). Multivariate analyses were performed using the Cox proportional hazard model. - Results - Low ypT-categories did not discriminate overall survival (ypT0: reference; ypT1: HR1.0/p = 0.909; ypT2: HR0.9/p = 0.845; ypT3: HR1.5/p = 0.184; ypT4: HR2.8/p = 0.004) and no difference was found between ypN1- and ypN2-disease (ypN0: HR0.4/p < 0.001; ypN1: reference; ypN2: HR1.1/p = 0.653; ypN3: HR1.7/p = 0.014). In esophageal adenocarcinoma the UICC-TNM- and AJCC-ypTNM-staging-system was able to predict survival for patients after NT, while in gastric cancer it failed to provide sufficient prognostic information. A simplified staging system provided better stratification after NT and was an independent prognosticator for both esophageal and gastric adenocarcinoma (stage I: reference; stage II: HR2.2/p = 0.005; stage III: HR4.1/p < 0.001). - Conclusion - Prognostic value of ypTN-categories seems limited. After NT the current UICC/AJCC-staging-system is able to predict survival in esophageal adenocarcinoma, but needs to be reevaluated in gastric cancer patients and modified if needed. A novel simplified staging system might be more practicable for patients after NT. |
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| DOI: | doi:10.1016/j.ejso.2018.06.030 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.1016/j.ejso.2018.06.030 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S0748798318311740 |
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| | DOI: https://doi.org/10.1016/j.ejso.2018.06.030 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | Esophageal cancer |
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| | Gastric cancer |
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| | Neoadjuvant treatment |
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| | Prognosis |
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| | Staging |
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| K10plus-PPN: | 1678846856 |
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| Verknüpfungen: | → Zeitschrift |
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Prognostic differences in 8th edition TNM staging of esophagogastric adenocarcinoma after neoadjuvant treatment / Peters, Leila [VerfasserIn]; 7 July 2018 (Online-Ressource)
