Status: Bibliographieeintrag
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| Verfasst von: | Mattila, Jaakko [VerfasserIn]  |
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| | Kokki, Krista [VerfasserIn] |
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| | Hietakangas, Ville [VerfasserIn] |
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| | Boutros, Michael [VerfasserIn] |
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| Titel: | Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content |
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| Verf.angabe: | Jaakko Mattila, Krista Kokki, Ville Hietakangas, and Michael Boutros |
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| E-Jahr: | 2018 |
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| Jahr: | September 13, 2018 |
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| Umfang: | 13 S. |
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| Illustrationen: | Illustrationen |
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| Fussnoten: | Gesehen am 17.10.2019 |
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| Titel Quelle: | Enthalten in: Developmental cell |
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| Ort Quelle: | Cambridge, Mass. : Cell Press, 2001 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 47(2018), 1, Seite 112-121, e1-e3 |
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| ISSN Quelle: | 1878-1551 |
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| Abstract: | The intestine is an organ with an exceptionally high rate of cell turnover, and perturbations in this process can lead to severe diseases such as cancer or intestinal atrophy. Nutrition has a profound impact on intestinal volume and cellular architecture. However, how intestinal homeostasis is maintained in fluctuating dietary conditions remains insufficiently understood. By utilizing the Drosophila midgut model, we reveal a novel stem cell intrinsic mechanism coupling cellular metabolism with stem cell extrinsic growth signal. Our results show that intestinal stem cells (ISCs) employ the hexosamine biosynthesis pathway (HBP) to monitor nutritional status. Elevated activity of HBP promotes Warburg effect-like metabolic reprogramming required for adjusting the ISC division rate according to nutrient content. Furthermore, HBP activity is an essential facilitator for insulin signaling-induced ISC proliferation. In conclusion, ISC intrinsic hexosamine synthesis regulates metabolic pathway activities and defines the stem cell responsiveness to niche-derived growth signals. |
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| DOI: | doi:10.1016/j.devcel.2018.08.011 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext ; Verlag: https://doi.org/10.1016/j.devcel.2018.08.011 |
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| | Volltext: http://www.sciencedirect.com/science/article/pii/S1534580718306816 |
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| | DOI: https://doi.org/10.1016/j.devcel.2018.08.011 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | hexosamine biosynthesis |
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| | homeostasis |
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| | insulin signaling |
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| | intestinal stem cells |
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| | Warburg effect |
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| K10plus-PPN: | 167903037X |
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| Verknüpfungen: | → Zeitschrift |
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Stem cell intrinsic hexosamine metabolism regulates intestinal adaptation to nutrient content / Mattila, Jaakko [VerfasserIn]; September 13, 2018 (Online-Ressource)
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