High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center

• Verfasst von: Mattke, Matthias [VerfasserIn]
• Verfasst von: Vogt, Kira [VerfasserIn]
• Verfasst von: Bougatf, Nina [VerfasserIn]
• Verfasst von: Welzel, Thomas [VerfasserIn]
• Verfasst von: Oelmann-Avendano, Jan Tobias [VerfasserIn]
• Verfasst von: Hauswald, Henrik [VerfasserIn]
• Verfasst von: Jensen, Alexandra [VerfasserIn]
• Verfasst von: Ellerbrock, Malte [VerfasserIn]
• Verfasst von: Jäkel, Oliver [VerfasserIn]
• Verfasst von: Haberer, Thomas [VerfasserIn]
• Verfasst von: Herfarth, Klaus [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Uhl, Matthias [VerfasserIn]
• Titel: High control rates of proton- and carbon-ion-beam treatment with intensity-modulated active raster scanning in 101 patients with skull base chondrosarcoma at the Heidelberg Ion Beam Therapy Center
• Verf.angabe: Matthias Mattke, Kira Vogt, Nina Bougatf, Thomas Welzel, Jan Oelmann‐Avendano, Henrik Hauswald, Alexandra Jensen, Malte Ellerbrock, Oliver Jäkel, Thomas Haberer, Klaus Herfarth, Jürgen Debus, and Matthias Uhl
• E-Jahr: 2018
• Jahr: [May 1, 2018]
• Umfang: 9 S.
• Illustrationen: Diagramme
• Fussnoten: First published: 22 February 2018 ; Gesehen am 17.10.2019
• Titel Quelle: Enthalten in: Cancer
• Ort Quelle: New York, NY : Wiley-Liss, 1948
• Jahr Quelle: 2018
• Band/Heft Quelle: 124(2018), 9, Seite 2036-2044
• ISSN Quelle: 1097-0142
• DOI: doi:10.1002/cncr.31298
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: carbon ion
• Sach-SW: chondrosarcoma
• Sach-SW: heavy ion
• Sach-SW: proton
• Sach-SW: radiotherapy
• Sach-SW: skull base
• K10plus-PPN: 1679031961

Abstract

BACKGROUND The current study compares the results of irradiation with protons and irradiation with carbon ions via a raster scan technique in patients with G1 and G2 skull base chondrosarcomas. METHODS Between 2009 and 2014, a total of 101 patients (40 men and 61 women) with a median age of 44 years (range, 19-77 years) were irradiated with carbon ions (79 patients) or protons (22 patients) via a raster scan technique at the Heidelberg Ion Beam Therapy Center. The median total dose was 60 Gy (relative biological effectiveness [RBE]) at 3 Gy per fraction for carbon ions and 70 Gy (RBE) at 2 Gy per fraction for protons. The median boost planning target volume was 38 cm3 (range, 8-133 cm3). Overall survival (OS) and local control (LC) were evaluated with the Kaplan-Meier method. RESULTS The median follow-up period was 40 months (range, 0.8-78.1 months). At the start of the irradiation, all patients had residual macroscopic tumors. Five patients (5%) developed a local recurrence during the follow-up. The 1-, 2-, and 4-year LC rates were 100%, 100%, and 100%, respectively, for protons and 98.6%, 97.2%, and 90.5%, respectively, for carbon ions. The OS rates during the same periods of time were 100%, 100%, and 100%, respectively, for protons and 100%, 98.5%, and 92.9%, respectively, for carbon ions. An age ≤ 44 years was associated with a trend for a better outcome. No toxicity worse than Common Toxicity Criteria grade 3 was observed after treatment. CONCLUSIONS No significant difference between carbon ions and protons in the therapy of skull base chondrosarcoma could be detected in these initial retrospective results. Cancer 2018;124:2036-44. © 2018 American Cancer Society.