| |  Online-Ressource |
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| Verfasst von: | Haubruck, Patrick [VerfasserIn]  |
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| | Heller, Raban [VerfasserIn] |
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| | Tanner, Michael Christopher [VerfasserIn] |
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| | Daniel, Volker [VerfasserIn] |
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| | Schmidmaier, Gerhard [VerfasserIn] |
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| | Bolourchi, Farhoud [VerfasserIn] |
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| | Moghaddam-Alvandi, Arash [VerfasserIn] |
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| | Fischer, Christian [VerfasserIn] |
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| Titel: | A preliminary study of contrast-enhanced ultrasound (CEUS) and cytokine expression analysis (CEA) as early predictors for the outcome of tibial non-union therapy |
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| Verf.angabe: | by Patrick Haubruck, Raban Heller, Michael C. Tanner, Volker Daniel, Gerhard Schmidmaier, Farhoud Bolourchi, Arash Moghaddam, and Christian Fischer |
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| E-Jahr: | 2018 |
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| Jahr: | 24 August 2018 |
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| Umfang: | 15 S. |
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| Fussnoten: | Gesehen am 17.10.2019 |
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| Titel Quelle: | Enthalten in: Diagnostics |
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| Ort Quelle: | Basel : MDPI, 2011 |
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| Jahr Quelle: | 2018 |
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| Band/Heft Quelle: | 8(2019,3) Artikel-Nummer 55, 15 Seiten |
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| ISSN Quelle: | 2075-4418 |
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| Abstract: | The current study investigates if contrast-enhanced ultrasound (CEUS) or cytokine expression analysis (CEA) evaluating vascularization are capable of predicting the outcome of non-union therapy. Patients with tibial non-unions were surgically treated and participated in our follow-up program including perioperative collection of blood as well as CEUS analysis. Two groups were formed: Responders in group 1 (G1, N = 8) and Non-Responders in group 2 (G2, N = 5). Serum cytokine expression and local microperfusion were compared and correlated to the radiologic outcome. Evaluation of TNF-α expression revealed significantly lower values prior to first surgery in G1 (G1: 9.66 ± 0.96 pg/mL versus G2: 12.63 ± 1.2 pg/mL; p = 0.045); whereas after treatment both CEA and CEUS indicated a higher potential for angiogenesis in Responders. Logistic regression modelling revealed the highest predictive power regarding eventual osseous consolidation for the combination of both CEUS and serum CEA. The results provide first evidence regarding a link between changes in the serum expression of distinct pro-angiogenic cytokines and alterations in the local microperfusion assessed via both non-invasive and radiation-free diagnostic modalities. In addition, a combination of CEUS and CEA is a promising novel tool in early prediction of the outcome of non-union therapy. |
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| DOI: | doi:10.3390/diagnostics8030055 |
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| URL: | Bitte beachten Sie: Dies ist ein Bibliographieeintrag. Ein Volltextzugriff für Mitglieder der Universität besteht hier nur, falls für die entsprechende Zeitschrift/den entsprechenden Sammelband ein Abonnement besteht oder es sich um einen OpenAccess-Titel handelt.
Volltext: https://doi.org/10.3390/diagnostics8030055 |
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| | Verlag: https://www.mdpi.com/2075-4418/8/3/55 |
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| | DOI: https://doi.org/10.3390/diagnostics8030055 |
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| Datenträger: | Online-Ressource |
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| Sprache: | eng |
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| Sach-SW: | bone regeneration |
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| | contrast-enhanced ultrasound |
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| | cytokine |
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| | diagnostics |
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| | non-union |
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| | prediction |
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| | revision surgery |
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| K10plus-PPN: | 1679045326 |
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| Verknüpfungen: | → Zeitschrift |
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¬A¬ preliminary study of contrast-enhanced ultrasound (CEUS) and cytokine expression analysis (CEA) as early predictors for the outcome of tibial non-union therapy / Haubruck, Patrick [VerfasserIn]; 24 August 2018 (Online-Ressource)
