Gadolinium leakage in ocular structures in optic neuritis

• Verfasst von: Förster, Alex [VerfasserIn]
• Verfasst von: Böhme, Johannes [VerfasserIn]
• Verfasst von: Groden, Christoph [VerfasserIn]
• Verfasst von: Wenz, Holger [VerfasserIn]
• Titel: Gadolinium leakage in ocular structures in optic neuritis
• Verf.angabe: Alex Förster, Johannes Böhme, Christoph Groden, Holger Wenz
• E-Jahr: 2019
• Jahr: October 2019
• Umfang: 3 S.
• Fussnoten: Gesehen am 18.10.2019
• Titel Quelle: Enthalten in: Journal of clinical neuroscience
• Ort Quelle: Burlington, Mass. : Harcourt, 1994
• Jahr Quelle: 2019
• Band/Heft Quelle: 68(2019), Seite 268-270
• ISSN Quelle: 1532-2653
• DOI: doi:10.1016/j.jocn.2019.05.050
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Contrast-enhanced
• Sach-SW: FLAIR
• Sach-SW: Gadolinium leakage in ocular structures
• Sach-SW: GLOS
• Sach-SW: Optic neuritis
• K10plus-PPN: 167911574X

Abstract

Background - We investigated the frequency of blood-retina barrier impairment in optic neuritis (ON) using gadolinium leakage in ocular structures (GLOS), a novel imaging marker on contrast enhanced fluid attenuated inversion recovery images (FLAIR). - Methods - In 12 patients with acute ON who underwent repeated MRI the presence of GLOS was noted on contrast-enhanced FLAIR. - Results - Bilateral GLOS was observed in 4 (33.3%): in 3 symmetrical, and in 1 asymmetrical. In the latter GLOS was ipsilateral to the ON. - Conclusions - GLOS may be observed frequently in ON. Asymmetrical GLOS may be caused by a more local effect of ON.