Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning 1H, 4He, 12C, and 16O ion-beams using an anthropomorphic phantom

• Verfasst von: Mein, Stewart [VerfasserIn]
• Verfasst von: Bauer, Julia [VerfasserIn]
• Verfasst von: Debus, Jürgen [VerfasserIn]
• Verfasst von: Abdollahi, Amir [VerfasserIn]
• Verfasst von: Mairani, Andrea [VerfasserIn]
• Titel: Dosimetric validation of Monte Carlo and analytical dose engines with raster-scanning 1H, 4He, 12C, and 16O ion-beams using an anthropomorphic phantom
• Verf.angabe: Stewart Mein, Benedikt Kopp, Thomas Tessonnier, Benjamin Ackermann, Swantje Ecker, Julia Bauer, Kyungdon Choi, Giulia Aricò, Alfredo Ferrari, Thomas Haberer, Jürgen Debus, Amir Abdollahi, Andrea Mairani
• E-Jahr: 2019
• Jahr: 11 July 2019
• Umfang: 9 S.
• Fussnoten: Gesehen am 21.10.2019 ; Im Titel sind die Zahlen 1, 4, 12 und 16 hochgestellt
• Titel Quelle: Enthalten in: Physica medica
• Ort Quelle: Amsterdam : Elsevier, 1996
• Jahr Quelle: 2019
• Band/Heft Quelle: 64(2019), Seite 123-131
• ISSN Quelle: 1724-191X
• DOI: doi:10.1016/j.ejmp.2019.07.001
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Anthropomorphic phantom
• Sach-SW: Dosimetry
• Sach-SW: GPU
• Sach-SW: Monte Carlo simulation
• Sach-SW: Particle therapy
• Sach-SW: Pencil beam algorithm
• K10plus-PPN: 1679193066

Abstract

With high-precision radiotherapy on the rise towards mainstream healthcare, comprehensive validation procedures are essential, especially as more sophisticated technologies emerge. In preparation for the upcoming translation of novel ions, case-/disease-specific ion-beam selection and advanced multi-particle treatment modalities at the Heidelberg Ion-beam Therapy Center (HIT), we quantify the accuracy limits in particle therapy treatment planning under complex heterogeneous conditions for the four ions (1H, 4He, 12C, 16O) using a Monte Carlo Treatment Planning platform (MCTP), an independent GPU-accelerated analytical dose engine developed in-house (FRoG) and the clinical treatment planning system (Syngo RT Planning). Attaching an anthropomorphic half-head Alderson RANDO phantom to entrance window of a dosimetric verification water tank, a cubic target spread-out Bragg peak (SOBP) was optimized using the MCTP to best resolve effects of anatomic heterogeneities on dose homogeneity. Subsequent forward calculations were executed in FRoG and Syngo. Absolute and relative dosimetry was performed in the experimental beam room using 1D and 2D array ionization chamber detectors. Mean absolute percent deviation in dose (|%Δ|) between predictions and PinPoint ionization chamber measurements were within ∼2% for all investigated ions for both MCTP and FRoG. For protons and carbon ions, |%Δ| values were ∼4% for Syngo. For the four ions, 3D-γ analysis (3%/3mm criteria) of FLUKA and FRoG presented mean passing rates of 97.0(±2.4)% and 93.6(±4.2)%. FRoG demonstrated satisfactory agreement with gold standard Monte Carlo simulation and measurement, superior to the commercial system. Our pre-clinical trial landmarks the first measurements taken in anthropomorphic settings for helium, carbon and oxygen ion-beam therapy.