Familial risk of pleural mesothelioma increased drastically in certain occupations

• Verfasst von: Kharazmi, Elham [VerfasserIn]
• Verfasst von: Chen, Tianhui [VerfasserIn]
• Verfasst von: Fallah, Mahdi [VerfasserIn]
• Verfasst von: Sundquist, Kristina [VerfasserIn]
• Verfasst von: Sundquist, Jan [VerfasserIn]
• Verfasst von: Albin, Maria [VerfasserIn]
• Verfasst von: Weiderpass, Elisabete [VerfasserIn]
• Verfasst von: Hemminki, Kari [VerfasserIn]
• Titel: Familial risk of pleural mesothelioma increased drastically in certain occupations
• Titelzusatz: a nationwide prospective cohort study
• Verf.angabe: Elham Kharazmi, Tianhui Chen, Mahdi Fallah, Kristina Sundquist, Jan Sundquist, Maria Albin, Elisabete Weiderpass, Kari Hemminki
• E-Jahr: 2018
• Jahr: 6 September 2018
• Umfang: 6 S.
• Fussnoten: Gesehen am 21.10.2019
• Titel Quelle: Enthalten in: European journal of cancer
• Ort Quelle: Amsterdam [u.a.] : Elsevier, 1992
• Jahr Quelle: 2018
• Band/Heft Quelle: 103(2018), Seite 1-6
• ISSN Quelle: 1879-0852
• DOI: doi:10.1016/j.ejca.2018.07.139
• Datenträger: Online-Ressource
• Sprache: eng
• Sach-SW: Familial risk
• Sach-SW: First-degree relatives
• Sach-SW: Mesothelioma
• Sach-SW: Occupation
• K10plus-PPN: 1679262688

Abstract

Objective - We aimed to explore the effect of occupation on familial risk of pleural mesothelioma in a nationwide cohort study design. - Method - The nationwide Swedish Family-Cancer Database includes all Swedes born after 1931 and their biological parents, totalling 16.1 million individuals with about 2.3 million cancer patients. Hazards ratios (HRs) were calculated adjusting for age, sex and region of residence. - Results - Having asbestos-related occupation in the absence of family history of mesothelioma increased risk of mesothelioma more than threefold (adjusted HR = 3.2, 95% confidence interval [CI]: 3.0-3.5). In those who had a history of mesothelioma in their first-degree relatives and an asbestos-related occupation, risk of mesothelioma dramatically increased compared with individuals without such occupations and family history (without chronic obstructive pulmonary disease [COPD] HR = 24, 95% CI: 15-39; with COPD 45, 95% CI: 15-141). In those who had a family history of mesothelioma and no history of an asbestos-related occupation, risk of mesothelioma did not show significant increase compared with those who had no family history of mesothelioma and no asbestos-related occupation (HR = 1.6; 95% CI: 0.7-3.8). - Conclusion - First-degree relatives of patients with pleural mesothelioma had a drastic risk of developing this malignancy in case of certain occupations, which shows a gene-environment interaction is probable in risk of mesothelioma.