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Verfasst von:Ahmad, Fareed [VerfasserIn]   i
 Döbel, Thomas [VerfasserIn]   i
 Schmitz, Marc [VerfasserIn]   i
 Schäkel, Knut [VerfasserIn]   i
Titel:Current concepts on 6-sulfo LacNAc expressing monocytes (slanMo)
Verf.angabe:Fareed Ahmad, Thomas Döbel, Marc Schmitz and Knut Schäkel
E-Jahr:2019
Jahr:22 May 2019
Fussnoten:Gesehen am 22.10.2019
Titel Quelle:Enthalten in: Frontiers in immunology
Ort Quelle:Lausanne : Frontiers Media, 2010
Jahr Quelle:2019
Band/Heft Quelle:10(2019) Artikel-Nummer 948, 13 Seiten
ISSN Quelle:1664-3224
Abstract:The human mononuclear phagocyte system consists of dendritic cells (DCs), monocytes and macrophages having different functions in bridging innate and adaptive immunity. Among the heterogeneous population of monocytes the cell surface marker slan (6-sulfo LacNAc) identifies a specific subset of human CD14- CD16+ non-classical monocytes, called slan+ monocytes (slanMo). In this review we discuss the identity and functions of slanMo, their contributions to immune surveillance by proinflammatory cytokine production, and cross talk with T cells and NK cells. We also consider the role of slanMo in the regulation of chronic inflammatory diseases and cancer. Finally, we highlight unresolved questions that should be the focus of future research.
DOI:doi:10.3389/fimmu.2019.00948
URL:Kostenfrei: Volltext ; Verlag: https://doi.org/10.3389/fimmu.2019.00948
 Kostenfrei: Volltext: https://www.frontiersin.org/articles/10.3389/fimmu.2019.00948/full
 DOI: https://doi.org/10.3389/fimmu.2019.00948
Datenträger:Online-Ressource
Sprache:eng
Sach-SW:Autoimmunity
 Cancer
 Infection
 Inflammation
 non-classical monocytes
 slan+ monocytes
 slanDCs
 slanMo
K10plus-PPN:1679294482
Verknüpfungen:→ Zeitschrift
 
 
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